Components as a part of drug composition must be well combined and mixed in order to obtain an even distribution in the total mass. Getting a homogeneous mass is considered a complicated and rather important technological process. While powders have different physical and chemical properties, namely: bulk density, fluidity, moisture, and dispersity. In this process, batch-type concrete mixers are used that have blades. As for the shape of the blades, they can be completely different, but most often use the Z-shape and worm blades.Drug Production

Wet Granulation Stage

The production of medicines undergoes the stage of granulation, such a process of converting raw materials into a powdered material. This is necessary in order to improve the flowability of the mixture and prevent delamination. The process of granulation can be both dry and wet. Wet granulation has a connection with the use of a liquid – a solution of an auxiliary substance. Dry granulation wets liquid or does not resort to this process at all. Also, such components can be used at a certain stage of preparing the material for drugs production.

We have considered the production of medications, namely the operation of wet granulation methods by pressing and rubbing. More often operations on mixing and creating an indiscrete mass by wetting a powder are utilized in combination with various granulating solutions at which the results are observed in one mixer. In rare cases, one unit can combine granulation. Such mixing is provided by forced vigorous stirring in a circle of particles and colliding them with each other.

Mixing Stage in Drugs’ Production

The production of drugs during the mixing process, in order to obtain a homogeneous mass, should last no more than five minutes. After this, to the premixing of the powder, a granular liquid is fed into the mixer, and now the mixture is stirred for ten minutes. After the granulated process has come to an end, it will be necessary to open the unloading valve, and on a slow rotation of the scraper pour out the finished product. When compared with drying, which occurs in drying chambers, a more promising option is the drying of pellets in the fluidized bed. The main advantage can be attributed to a high level of intensive process, the potential for complete automation of the process, and a reduction in specific require much energy.

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Production of medications to the top of technical perfection and perspective can be attributed to the apparatus in which the operations of granulation, dusting, drying and mixing are combined. If we take into account the fact that the process of wet granulation is applied, then this process can be performed in different apparatuses, and after drying the granules, it is possible to start the operation of dry granulation. After the drying completion granules will not have a uniform mass but contain lumps, the granules are sent to the pulping machine. Then they are peeled apart to form dust.

Considering that the granules that were obtained after the dry process must have a rough surface. As a result, this makes it difficult to apply hoppers for further drug production. In addition, the pellets can adhere to the plunger and stick to the tablet press. This can cause weight loss and flaws in the tablets. In this process, free application of the crushed substances is carried out, and by the method of dusting, disintegrating and sliding substances are introduced into the tablet powder.

Dry Granulation Stage

Now consider dry granulation, in many cases, if you take the drug, it is decomposed with water, and resorted to the process of dry granulation. To do this, you will need to press the briquettes out of the powder, then subject them to breaking, and thus get the grain. After the grain has cleaned from the dust, they are subjected to tableting. Today under dry technology such a method is taken, where the powdered material is subjected to initial compaction, namely pressing. As a result, granulates are obtained which are subjected to tableting, i.e., secondary consolidation. If we consider the initial consolidation, then gluing dry substances are introduced into the mass, which, under pressure, ensure the adhesion of the particles to hydrophobic and hydrophilic substances.

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The drugs have undergone a rather difficult process of production – and such pills you may find in online pharmacies – it doesn’t matter Canadian or not. Special organizations allow the sale of such drugs when they are sure all the requirements are met.

Stages of Drugs’ Production

1. choice of biotarget for creating a new drug
2. choice of low-molecular composition with a required pharmacological action:
  • components selection
  • computer selection
  • synthesis
  • screening
  • toxicity examination
3. preclinical trials on animals
4. clinical trials on human
5. patenting, state examination, registration of preparation
6. release on the pharmaceutical market