Levitra (Vardenafil)

1. What is Levitra?
2. Indications for Use
3. Composition of the Drug
4. Mechanism of Action
5. Instructions for Use
6. Dosage
7. Overdose
8. Contraindications
9. Side effects
10. Drug Interactions
11. Is it possible to Combine Levitra and Alcohol?
12. Levitra vs Cialis vs Viagra
13. New Pharmaceutical Form
14. Effectiveness and Safety Studies
15. Causes of Preferences

Levitra – All You Need to Know about the Drug

What Is Levitra?

Levitra is a powerful means, used for erectile function disorders and premature ejaculation treatment in men. Since erectile dysfunction symptoms are faced not only by older generation but also by young people.Problems associated with achieving and maintaining an erection can occur as a result of the negative impact of a number of factors:

• poor environmental conditions;
• poor nutrition;
• common stress and poor lifestyle.

Levitra 20 mg is one of the most popular and demanded erectile dysfunction drugs. The main advantage of this drug is a long-term and qualitative impact, providing a strong erection.

The drug structure includes safe ingredients that do not cause addiction, even in case of long-term use, and thanks to its versatility, it is suitable for people of all ages.

Despite the fact that the drug appeared recently on Canadian Healthcare Mall, it has managed to obtain a significant number of favorable reviews and fans.

If you need this drug, you can buy it in pills, 20 mg of active ingredient in each. The back side of the blister contains information about a shelf-life period of pills and their composition.

The active ingredient of Levitra is vardenafil. It is characterized by rapid absorption and penetration into blood, which allows drug action to appear within 30 – 45 minutes after administration.

When taken regularly, vardenafil eliminates the problem of premature ejaculation, restores hormone production, in particular – testosterone, as well as increases duration of sexual intercourse by several times.

The fundamental point is the fact that this drug is not hormonal, it also has no effect on the psyche. Vardenafil 20 mg selectively increases blood flow to penis cavernous bodies, preventing its outflow and providing natural erection of quite a long duration, which is proved by reviews about Levitra. This drug is not a means for excitation, it only guarantees you a 100% natural erection if you have a really strong sexual desire.

Main advantages of the product:

• effectively solves the problem of sexual dysfunction;
• high performance – many people study reviews about Levitra and basing on them put the drug to one category with Cialis or Viagra, which is not true, it is several times higher, since according to clinical trials of leading medical centers, it was proved that concerning effectiveness it is 10 times better than Viagra and almost 13 times – than Cialis;
• a number of studies have revealed high productivity of vardenafil in men with severe diabetes and prostate gland after surgery;
• allows to be ready for sexual relations in all circumstances;
• characterized by natural action;
• there are no random erections;
• compatible with alcoholic drinks and any food;
• rapidly shows its effect;
• suitable for all ages;
• does not cause hormonal disruptions;
• does not affect nervous and circulatory system;
• has no addiction syndrome;
• does not affect the health of future children;
• has almost no contraindications;
• side effects are very rare.

The product has improved formula, despite the fact that price for Levitra is quite low at such high level of quality, it causes side effects extremely rare. At risk are patients who have cardiovascular diseases or myocardial infarction, if during exercise dyspnea and dull pain in sternum appear, the drug should be used only after consulting a doctor.

This preparation is produced in the form of round double radius light-orange pills, one side of which has figure indicating a quantity of the active substance, on the other – sign in the form of a cross, indicating manufacturer – German pharmaceutical company «Bayer».

Levitra pills contain 5, 10 or 20 mg of active substance, they are packed into blisters by 1, 2, 3, 4 pieces. One box contains 1, 2 or 3 blisters.

Indications for Use

Its main purpose is a treatment for erectile dysfunction. It is indicated for men who have difficulties with achieving and maintaining an erection. Also, the drug is used for premature ejaculation, low sexual activity and overwork. If a patient suffers from the inability to carry out full sexual intercourse, the drug will help to resolve this problem.

In addition, its regular use makes men more confident in themselves and their abilities, allowing to extend sexual intercourse.

Erectile dysfunction disorders can be caused by physiological and psychological factors. Vardenafil affects the physical health of men, it contributes to relaxation, effectively improves potency, weakened as a result of sexually transmitted diseases or tiredness.

The drug can be used to improve quality of sexual life, prolonging sexual intercourse, increasing the sensitivity of penis and erogenous zones. Furthermore, the product has a positive effect on an overall hormonal system, so it is often used in the complex treatment of prostatitis and impotence, as well as during initial stages of infertility. It is indicated for men of all ages.

Composition of the Drug

The main ingredient is vardenafil. It is responsible for active blood supply to the penis, increasing erection and helping control over ejaculation.

In moderate amounts and absence of intolerance, vardenafil is harmless to health and can be taken in combination with a small amount of alcohol.

Drug action is directed to smooth muscles of the penis. It has a relaxing effect and increases the sensitivity of both penis and erogenous zones.

Auxiliary components are:

• lactose;
• magnesium stearate;
• sodium;
• starch;
• talc.

They by several times improve the effect of vardenafil.

Mechanism of Action

Before you buy the drug, it is desirable to get acquainted with the principle of its action.

Usually, during sexual excitement, blood flows to penile tissues, causing the erection. But if in pelvic area vascular malfunction appears, blood flow to the penis is blocked, resulting in the development of impotence. Under its effect, cavernous bodies muscles relax, causing expansion of penile arteries and increasing their capacity. As a result of these processes, blood flows to the penis, causing a natural erection. But in this case, excitement comes not without reason, but only as a result of sexual stimulation. When sexual intercourse is completed, erection disappears naturally.

Effect of the drug is fully manifested at first reception. Usually, at further usage, its dosage is reduced, but performance is not changed.

But erection occurs only in presence of sexual stimulation, as only during sexual stimulation nerve endings release nitric oxide, which activates guanylate cyclase enzyme responsible for a chain of processes necessary for eliminating erectile dysfunction.It is important to remember the main principle of an action – it does not create an erection, it enhances it on the background of sexual stimulation.

The effect is already seen 20 – 25 minutes after administration and this action time in most cases reach up to 5 – 6 hours.

Instructions for Use

According to instruction on Canadian Health and Care Mall, this medication is taken orally, regardless of meals, with a glass of water, not chewing the pill. Levitra may be combined with alcohol consumption (maximum – 100 grams of liquor), and also with vitamins, dietary supplements and a number of drugs. The drug is taken 30 – 60 minutes before anticipated sexual intercourse once a day. Its effect is maintained for 6 hours, for this reason, even if take it 4 – 6 hours before sexual intercourse, the erection will still be strong enough. According to some reviews, erection can be stable even within 8 – 10 hours.

Dosage

Instruction for Levitra recommends starting drug reception with initial dosage size of 10 mg, dosage adjustment for elderly patients is not required.

• In patients with mild hepatic insufficiency dosage adjustment is not required. In patients with moderate hepatic impairment, the initial dosage should be 5 mg a day. Further, depending on efficacy and treatment tolerability dosage can be increased to 10 mg and then to 20 mg.
• Patients with mild and moderate renal function impairment dosage adjustment is not required.

The maximum Levitra dose daily should not exceed 20 mg. Such dosage is allowed in case of weakly pronounced effect after taking 10 mg of the drug, at diabetes or prostatectomy.

Due to individual characteristics of each body, as well as personal tolerability of suitable dosage often is determined by men themselves by trial and error method (of course within reasonable limits). But in any case, before taking such medications it is extremely important to consult a doctor. Also, before taking this medication, you must carefully read instruction, make sure there are no contraindications, learn about possible side effects.

Overdose

Symptoms: there were cases of receiving Levitra 80 mg 1 time/day and 40 mg 1 time/day for more than 4 weeks without developing serious adverse reactions. However, at the same time, when used in dosage of 40 mg 2 times/day there are marked back pains without signs of toxic effects on the muscular and nervous system.

Treatment: symptomatic and supportive therapy. Since vardenafil strongly binds to plasma proteins and only a small amount of the drug is excreted by kidneys, dialysis unlikely to be efficient.

Contraindications

Instruction for use states that the drug should not be used at:

• hypersensitivity to main or auxiliary components of the drug;
• by women and children under the age of 16;
• by men suffering from severe cardiovascular diseases (arterial hypertension and hypotension, cardiac angina, and others);
• phenylketonuria;
• atherosclerosis;
• carcinogenic tumors.

Vardenafil should be taken only under medical supervision at:

• penis deformation;
• by patients who have recently had blood stroke, heart attack or other diseases after which sexual activity is prohibited;
• kidney diseases;
• liver insufficiency;
• ulcer exacerbation;
• low blood pressure;
• predisposition to hemorrhages;
• narrowing of aorta;
• left ventricle obstruction;
• predisposition to priapism;
• cavernous fibrosis;
• degenerative diseases of retina.

Specific instructions that should be read

• drug effectiveness is not reduced at simultaneous intake with alcohol and/or fatty foods;
• strictly prohibited the concomitant use of various sexual stimulation;
• grapefruit or grapefruit juice should be excluded;
• in patients with liver diseases result after taking Levitra is somewhat lower than in relatively healthy men.

In presence of other chronic diseases and regular intake of medications, before using these pills you should undergo a medical examination and get professional advice.

Effects on ability to operate vehicles and mechanisms
Before prescribing the drug to patients who are operating vehicles and work with mechanisms it is necessary to clarify their individual response.

Side Effects

Levitra is usually well tolerated, side effects are mild or moderate.

Central and peripheral nervous system:

• ≥10% – headache;
• ≥1% – dizziness;
• ≥0,1% –
• ≥0,01% –

Cardiovascular system:

• ≥10% – hot flushes (sudden intermittent facial flushing, heat sensation);
• ≥0,1% –
• ≥0,01% –

Digestive system:

• ≥1% –
• ≥0,1% –

Respiratory system:

• ≥1% –
• ≥0,1% –
• ≥0,01% –

Organs of vision:

• ≥0,1% –
• ≥0,01% –

Dermatological reactions:

• ≥0,1% –

Musculoskeletal system:

• ≥0,1% –
• ≥0,01% – 0,01% –

Other:

• ≥0,01% –

There are rare postmarketing reports of cases of non-arteritic anterior ischemic optic neuropathy (NAAION), which leads to impaired vision, including permanent loss of vision associated in time with PDE-5 inhibitors intake, in patients many of which have related risk factors for development of this condition, such as anatomical defect of optic nerve, age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia and smoking. It not determined whether NAAION development is connected directly with PDE-5 inhibitors or with concomitant cardiovascular risk factors and anatomical defects or a combination of these factors or other causes.

Reported cases of visual disturbances, including temporary or permanent loss of vision, which are associated in time with taking PDE-5 inhibitors. It is not determined whether these cases are connected directly with PDE-5 inhibitors reception or concomitant cardiovascular risk factors or other causes.

These adverse reactions are completely harmless. They disappear quickly and do not require receiving additional medications.

Drug Interactions

Vardenafil is metabolized predominantly involving liver enzyme of P450 cytochrome system, namely CYP3A4, as well as with some participation of CYP3A5 and CYP2S isozymes. Inhibitors of these enzymes may reduce vardenafil clearance. With simultaneous use with ketoconazole, itraconazole, indinavir and ritonavir (potent inhibitors of CYP3A4) you can expect the significant increase of vardenafil concentrations in blood plasma.

Simultaneous application of cimetidine (400 mg 2 times/day), which is a non-specific inhibitor of P450 cytochrome system isoenzymes, does not affect AUC and Cmax of vardenafil (20 mg).

At concomitant use with (5 mg) erythromycin (500 mg 3 times/day), which is a CYP3A4 inhibitor, causes the increase in vardenafil AUC by 4 times (300%) and Cmax increased by 3 times (200%).

Ketoconazole (200 mg), as a potent CYP3A4 inhibitor, when used with vardenafil (5 mg), causes the increase in AUC of vardenafil by 10 times (900%) and Cmax – by 4 times (300%).

At simultaneous use (10 mg) and HIV-protease inhibitor indinavir (800 mg 3 times/day), there is an increase in vardenafil AUC by 16 times (1500%) and Cmax – by 7 times (600%). 24 hours after administration, vardenafil concentration in blood plasma is about 4% of its Cmax.

At simultaneous use with Levitra (5 mg), ritonavir (600 mg 2 times/day) increases Levitra Cmax by 13 times and its total daily AUC rate – by 49 times. Interaction is explained by the fact that ritonavir, as a potent CYP2C9 and CYP3A4 inhibitor, blocks hepatic metabolism of the main ingredient. Ritonavir significantly lengthens T1/2 of vardenafil to 25,7 hours.

In healthy volunteers, this ed drug (10 mg) received 24 hours before administration of nitroglycerine (400 mcg sublingual) does not enhance its hypotensive effect, at dosage of 20 mg 1 – 4 hours before application of nitrates (400 mcg sublingual) enhances their hypotensive action, but when prescribed for 24 hours, hypotensive action enhancement does not occur.

Vardenafil (20 mg) does not alter AUC and Cmax parameters of glibenclamide (glyburide at the dosage of 3,5 mg) at their joint use, and vice versa.

Pharmacokinetic and pharmacodynamic interaction (effect on prothrombin time and coagulation factors II, VII, X) is not observed at the combination of vardenafil (20 mg) with warfarin (25 mg).

There has been no significant pharmacokinetic interaction between Levitra (20 mg) and nifedipine (30 mg or 60): Vardenafil in supine position causes an additional reduction in systolic and diastolic blood pressure at average by 5,9 mm Hg and 5,2 mm Hg respectively.

Since it is known that alpha-blockers cause the reduction in blood pressure, especially postural hypotension and syncope, a question of the interaction of alpha-blockers when used together was carefully studied. Two studies were conducted on drug interactions in healthy volunteers with normal blood pressure receiving alpha-blockers tamsulosin or terazosin with rapid dosage increase to maximal or close to them within 14 days or less. After adding to this therapy Levitra, hypotension occurred in a significant number of study participants. Among those receiving terazosin, arterial hypotension (systolic blood pressure when standing below 85 mm Hg) developed more frequently if Levitra and terazosin were administered so as to reach Cmax coincidence in time than if Cmax diverged in time by 6 hours. These studies may have limited clinical relevance because they were conducted in healthy volunteers, and also after forced titration of doses (so that study participant failed to achieve stabilization of blood pressure in patients receiving alpha-blockers).

Studies of drug interactions were also conducted in patients with benign prostatic hyperplasia (BPH) receiving stable doses of tamsulosin or terazosin. When appointing the doses of 5, 10 or 20 mg for patients who received stable doses of tamsulosin, the additional decrease in blood pressure was not observed. At the single reception of Levitra 5 mg and tamsulosin at the dosage of 0,4 mg in 2 out of 21 patients, orthostatic hypotension with the drop in systolic blood pressure below 85 mm Hg was observed. When receiving 5 mg and tamsulosin with 6-hour interval, systolic orthostatic hypotension with the drop in blood pressure less than 85 mm Hg also developed in 2 out of 21 patients. In the subsequent study, at the single reception at the dosage of 10 mg and 20 mg and tamsulosin at the dosage of 0,4 mg and 0,8 mg, cases of the orthostatic drop in systolic blood pressure below 85 mm Hg have not been registered. At the single reception of 5 mg and terazosin at the dosage of 5 mg or 10 mg, one out of 21 patients observed symptomatic postural hypotension. When receiving at the dosage of 5 mg and terazosin with 6-hour interval, cases of blood pressure drop did not appear. The results should be taken into account when deciding on the time of prescribing.

Combined prescription of Levitra and alpha-blocker is permissible only in presence of stable rates of blood pressure in patients receiving alpha-blockers, while Levitra should be administered in a minimum recommended the dosage of 5 mg.

Concomitant use of digoxin (0,375 mg) and Levitra (20 mg) every other day for 14 days is not accompanied by drug interactions.

The single dose of Maalox (antacid, magnesium hydroxide/aluminum hydroxide) did not affect vardenafil AUC and Cmax.

Bioavailability of vardenafil (20 mg) was also not affected by its combination with histamine H2-receptor blockers – ranitidine (150 mg, 2 times/day) and cimetidine (400 mg, 2 times/day).

Levitra (10 mg and 20 mg) did not affect the duration of hemorrhages when used as monotherapy and in combination with acetylsalicylic acid at low dosage (2 pill of 81 mg).

This drug (20 mg) did not potentiate the hypotensive effect of ethanol (0,5 g/kg of body weight), the pharmacokinetics of vardenafil is not disturbed.

Aspirin, ACE inhibitors, beta-blockers, diuretics, and hypoglycemic agents (sulfonylureas and metformin), weak CYP3A4 inhibitors do not affect vardenafil pharmacokinetics.

Is it possible to Combine Levitra and Alcohol?

According to experts, these two substances have different origin and structure. Alcohol contained in similar beverages has relaxing and harmful effects on body simultaneously. Levitra, as a drug for impotence, enhances erection at sexual stimulation. Taking large quantities of these means is not recommended, as there is a risk of occurrence of adverse effects.

However, many men due to various circumstances can sometimes take Levitra with alcohol. And in these cases, they often talk about the absence of significant unpleasant consequences for their organism. Is it true? Try to understand with Canadian HealthCare Mall.

Levitra is a drug that is prescribed to men with problems with erectile dysfunction. Regular intake of this medicine helps to enhance erection during sexual stimulation. This medication admission is accompanied by rapid absorption and instant effect.

Reviews of men taking this drug are only positive. Also, many men say about the absence of side effects, if after drinking alcohol (not more than 200 grams) take Levitra. But do not believe these prejudices and try to take medicine separately from alcohol-containing beverages.

According to doctors, not every man’s body is able to combine reception of Levitra with alcohol. Depending on individual specifics of the body, this combination can be dangerous, especially if an amount of alcohol in the body is higher than permissible standards by several times. Moreover, drug composition includes an enormous number of active compounds which may be contraindicated for some people or cause symptoms of hypersensitivity. Based on numerous studies conducted in many hospitals, it was found that this drug should be taken after consultation with attending the doctor.

Of course, this medicine has some adverse effects on the liver structure at its cleavage. This medication is able to influence negatively on liver cells, so it should be taken in prescribed dosages.

If the body is sober, vardenafil begins to actively influence relevant organs of urogenital system and stimulate them to work. As a result, a man in a short period of time is already starting to feel much better, he feels a burst of energy for further sexual activity.

In the case when the body is filled with a lot of ethanol, its metabolism in the liver is delayed. As a result, an action of the drug can be very slow and a man does not get the desired effect on time. Therefore, you should not take these substances together, as one begins to act and the other remains in «waiting» stage.

Is it possible to take this drug by individuals, constantly consuming alcohol-containing beverages? Of course, such people have already disrupted the normal operation of the liver. Therefore, taking Levitra, even in small doses, a man begins to feel severe pains on right side. The reason for this is the inability of liver cells at an accelerated pace to begin processing received medication.

It is worth considering the fact that active ingredient is intended to provide sober men with timely assistance, not alcoholics of the third stage. Therefore, very drunk men should not take medication in order to avoid causing harm to own body.

If such situation still appears, when it is necessary to combine alcohol with this medication, you must adhere to the following guidelines:

• do not get completely drunk;
• try to take medication at the beginning of sobering upstage;
• do wash the drug down with alcohol;
• do not take other pills.

If ignore this recommendation the following symptoms of overdose may occur:

• nausea;
• headache;
• weakness;
• vomiting.

In this case, you should drink as many fluids (water) as possible for early elimination of drug components from the body. If you feel worse seek help from the medical institution.

Levitra vs Cialis vs Viagra

At the moment, the most effective drugs for the treatment of erectile dysfunction are Viagra, Cialis and Levitra. Very often people ask which of these drugs is the best, what to choose? The effect of each of these drugs is a little different from each other, and Canadian Health&Care Mall will try to provide you with basic information about these differences. All three drugs for the best effect require sexual excitement.

Viagra vs Cialis

In comparison – «which is better – Viagra or Cialis», in terms of compatibility with food, the situation is as follows: Viagra is recommended to be taken on an empty stomach, Cialis works equally well regardless of the meal. Efficacy may be slightly reduced after fatty foods consumption.

Viagra vs Levitra

To the next question – «which is better – Viagra or Levitra», referring to duration of action, the following answer can be given: Cialis has the greatest duration (36 hours), the second place in this comparison takes Levitra with its 10 – 12 hours and only the third place is given to Viagra, effect of which lasts 5 – 6 hours.

General Characteristics

An advantage of all 3 drugs is few side effects. The most common are hot flushes, headache, dizziness, nasal congestion. These side effects were observed in approximately 10% of patients who were taking one of the drugs. You should also know that individual characteristics of organism require using only one of these drugs. The action of Viagra is studied thoroughly, it is a powerful drug with a very short duration of action. The advantage of Cialis is its long time of exposure, which allows having sexual intercourse at any time during drug action. Levitra is the safest drug that causes the least number of side effects, its performance is not affected by food and drinks.

From the above it can be concluded that in comparison Viagra vs Cialis vs Levitra there is no clearly defined leader, application of these drugs depends on individual characteristics of the body of each person. These means are medications and the only doctor can prescribe or prohibit them. For one patient Viagra will be the best, while others prefer Levitra and Cialis. It is an individual choice.

We should not forget about bad habits, such as smoking, which can also disrupt potency.

New Pharmaceutical Form

Phosphodiesterase type 5 (PDE-5) inhibitors drugs are recommended as first-line agents for erectile dysfunction treatment. Currently, the market presents four of them: sildenafil, udenafil, vardenafil and tadalafil. These compounds are available in the form of pills which are quickly absorbed in the gastrointestinal tract. But the creation of Levitra in the form of conventionally coated pills has not stopped researchers, and a new form of the drug has been established – dissolving on the tongue. This happened due to the fact that both patients and clinicians believe that rapid onset of action, greater bioavailability (compared to film-coated pills) and ease of use is an important attribute of oral erectile dysfunction drug therapy.

The pill dissolves in the mouth for a few seconds and does not require water which allows men to more flexibly manage their sexual activity, ensures easy administration and high efficiency.

Effectiveness and Safety Studies

16-week double-blind multicenter randomized placebo-controlled parallel-group study «POTENT I», conducted in 40 centers across Europe and South Africa, was aimed at studying efficacy and safety of a new preparation – generic Levitra. Participants were men aged 18 years and older, who suffered from erectile dysfunction for at least 6 months, who are in stable heterosexual relationships for at least 6 months and motivated for erectile dysfunction treatment. These men had at least two of four unsuccessful attempts to perform sexual intercourse on separate days. Evaluation of treatment quality was carried out according to IIEF criteria and sexual profile scale. Additionally, there were assessed answers to questions about satisfaction with treatment and health state in general.

Out of 409 men surveyed (54,8% of those were aged 65 and older), 355 were included in the study. Patients were randomized in groups receiving Levitra (183 men) or placebo (172). Course duration was 12 weeks. The therapy effect was significantly higher compared to placebo for all primary (IIEF-EF, SEP2, SEP3) and secondary efficacy parameters (p Levitra therapy was significantly more effective than placebo for all primary and secondary efficacy parameters (p According to researchers estimates, side effects were mainly mild to moderate severity and were similar in frequency and type to those in treatment with film-coated Levitra pills. Thus, as authors of the study say, treatment with Levitra 10 mg significantly improves erectile function, effective and well tolerated in the broad population of men with erectile dysfunction.

M. Sanford confirms that Levitra in a dosage equivalent to film-coated pill provides somewhat larger impact. Thus, two formulations are not interchangeable. Analyzing results of combined researches POTENT I and II, authors suggest that this preparation improved erectile function regardless of age, the severity of the disease and presence or absence of concomitant diseases with minimally pronounced adverse reactions.

Thus, the spectrum of use for erectile dysfunction treatment drugs has increased by innovative form, which ensures rapid and necessary impact, high efficiency and safety. The drug is most comfortable for reception and therefore preferable to previously manufactured PDE-5 inhibitors.

Causes of Preferences

For men, the most important requirements for a drug for erectile dysfunction treatment are (in descending order of importance): «acts every time», «increases penis elasticity», «fast action and simple use», «gives self-confidence in sexual abilities». An important consequence of taking the pill has to be not only «better and longer sex», but spontaneity and flexibility of sexual life.

«ACCEPTANCE» study evaluated the degree of preference of PDE-5 inhibitors pills forms, including pills, dissolving in an oral cavity, among patients suffering from erectile dysfunction. Almost all men with erectile dysfunction, who participated in the study (not using PDE-5 inhibitors – 95%, use now – 92%, used in the past – 95%) got a positive opinion about Levitra in the form of pills, dissolving in the mouth, mainly due to ease of use. When men, suffering from erectile dysfunction, were asked about what they particularly liked about the product, certain positive characteristics were named combination of product features (rapid dissolution and method of receiving/form) and convenience (no need to drink water/liquid, simple and easy reception). According to the study, most men said that they would be likely to refuse from their current drugs for erectile dysfunction treatment in favor of pills dissolving in the mouth. There are also other factors that determine patient’s adherence to orally dispersible tablets, in particular disorders of swallowing, an inconvenience of swallowing large quantities of liquid or nausea. Dysphagia or difficulty with swallowing periodically occur in 35% of the population under influence of any factor associated with aging or certain medical conditions, such as cerebral vessels.

Thus, the original form was developed, with mint flavor (menthol flavor due to additives), able to dissolve in the mouth during several seconds without the need to wash it down with water. It can be taken with or without food, as it does not interact with products, including those containing large amounts of fat and calories. Concomitant use of Levitra and food does not affect pharmacokinetics and pharmacodynamics. The new form is presented in a stylish black color package of credit card size with special elegant design and easy to use.

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