Levitra is a trade name for Vardenafil, a new means for male erectile dysfunction treatment. Its effect is similar to Viagra action, but Levitra is more effective in many cases and has different dosage regimen.
This article contains all information you need to know before you take Canadian Pharmacy Levitra.
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Drug Category:Men's Health
Levitra Application:Erectile Dysfunction, Erection, ED, Impotence
Levitra Generic names:Vardenafil, Vivanza
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- What is Levitra?
- Indications for Use
- Composition of the Drug
- Mechanism of Action
- Instructions for Use
- Specific instructions that should be read before using Levitra
- Side effects
- Drug Interactions
- Is it possible to Combine Levitra and Alcohol?
- Levitra vs Cialis vs Viagra
- Is it possible to Combine Levitra and Alcohol?
- Levitra vs Cialis vs Viagra
- New Form of Levitra
- New Levitra Efficacy and Safety Studies
- Causes of Levitra Preferences
Canadian Pharmacy Levitra – All You Need to Know about the Drug
What Is Levitra
Many people wonder: What is Levitra and how does it work? How long does Levitra last? How to take Levitra for best results? and many similar questions. Levitra is a powerful means, used for erectile function disorders and premature ejaculation treatment in men. Since erectile dysfunction symptoms are faced not only by older generation but also by young people.Problems associated with achieving and maintaining erection can occur as a result of negative impact of a number of factors:
- poor environmental conditions;
- poor nutrition;
- common stress and poor lifestyle.
Generic Levitra 20 mg is one of the most popular and demanded erectile dysfunction drugs. The main advantage of this drug is long-term and qualitative impact, providing strong erection.
The drug structure includes safe ingredients that do not cause addiction, even in case of long-term use, and thanks to its versatility, it is suitable for people of all ages.
Despite the fact that the drug appeared recently on Canadian Healthcare Mall, it has managed to obtain a significant number of favorable reviews and fans.
If you need Levitra, you can buy it in pills, 20 mg of active ingredient in each. Back side of the blister contains information about shelf-life period of pills and their composition.
Active ingredient of generic Levitra is vardenafil. It is characterized by rapid absorption and penetration into blood, which allows drug action to appear within 30 – 45 minutes after administration.
When taken regularly, vardenafil eliminates problem of premature ejaculation, restores hormone production, in particular – testosterone, as well as increases duration of sexual intercourse by several times.
Fundamental point is the fact that this drug is not hormonal, it also has no effect on psyche. Vardenafil 20 mg selectively increases blood flow to penis cavernous bodies, preventing its outflow and providing natural erection of quite a long duration, which is proved by reviews about Levitra 20 mg. This drug is not a means for excitation, it only guarantees you a 100% natural erection if you have a really strong sexual desire.
Main advantages of the product:
- effectively solves problem of sexual dysfunction;
- high performance – many people study reviews about Levitra and basing on them put the drug to one category with Cialis or Viagra, which is not true, it is several times higher, since according to clinical trials of leading medical centers, it was proved that concerning effectiveness it is 10 times better than Viagra and almost 13 times – than Cialis;
- a number of studies have revealed high productivity of vardenafil in men with severe diabetes and prostate gland after surgery;
- allows to be ready for sexual relations in all circumstances;
- characterized by natural action;
- there is no random erections;
- compatible with alcoholic drinks and any food;
- rapidly shows its effect;
- suitable for all ages;
- does not cause hormonal disruptions;
- does not affect nervous and circulatory system;
- has no addiction syndrome;
- does not affect health of future children;
- has almost no contraindications;
- side effects are very rare.
The product has improved formula, despite the fact that price for Levitra is quite low at such high level of quality, it causes side effects extremely rare. At risk are patients who have cardiovascular diseases or myocardial infarction, if during exercise dyspnea and dull pain in sternum appear, the drug should be used only after consulting a doctor.
Levitra is produced in the form of round double radius light-orange pills, one side of which has figure indicating quantity of active substance, on the other – sign in the form of a cross, indicating manufacturer – German pharmaceutical company «Bayer».
Levitra pills contain 5, 10 or 20 mg of active substance, they are packed into blisters by 1, 2, 3, 4 pieces. One box contains 1, 2 or 3 blisters.
The main purpose of generic Levitra is treatment of erectile dysfunction. Levitra is indicated to men who have difficulties with achieving and maintaining erection. Also, the drug is useful for premature ejaculation, low sexual activity and overwork. If a patient suffers from inability to carry out full sexual intercourse, the drug will help to resolve this problem.
In addition, regular use of Levitra makes men more confident in themselves and their abilities, allowing to extend sexual intercourse.
Erectile dysfunction disorders can be caused by physiological and psychological factors. Vardenafil affects physical health of men, it contributes to relaxation, effectively improves potency, weakened as a result of sexually transmitted diseases or tiredness.
The drug can be used to improve quality of sexual life, prolonging sexual intercourse, increasing sensitivity of penis and erogenous zones. Furthermore, the product has positive effect on overall hormonal system, so it is often used in complex treatment of prostatitis and impotence, as well as during initial stages of infertility. Levitra is indicated to men of all ages.
The main ingredient of Levitra is vardenafil. Vardenafil is responsible for active blood supply to penis, increasing erection and helping control over ejaculation.
In moderate amounts and absence of intolerance, vardenafil is harmless to health and can be taken in combination with small amount of alcohol.
Drug action is directed to smooth muscles of penis. It has relaxing effect and increases sensitivity of both penis and erogenous zones.
Levitra also contains other auxiliary components:
- magnesium stearate;
They by several times improve effect of vardenafil.
Before you buy the drug, it is desirable to get acquainted with principle of its action.
Usually during sexual excitement, blood flows to penile tissues, causing erection. But if in pelvic area vascular malfunction appears, blood flow to penis is blocked, resulting in development of impotence. Under vardenafil effect, contained in Levitra, cavernous bodies muscles relax, causing relaxation and expansion of penile arteries and increasing their capacity. As a result of these processes blood flows to penis, causing natural erection. But in this case excitement comes not without reason, but only as a result of sexual stimulation. When sexual intercourse is completed, erection disappears naturally.
Effect of the drug is fully manifested at first reception. Usually, at further usage its dosage is reduced, but performance is not changed.
But erection occurs only in presence of sexual stimulation, as only during sexual stimulation nerve endings release nitric oxide, which activates guanylate cyclase enzyme responsible for chain of processes necessary for eliminating erectile dysfunction.It is important to remember the main principle of Levitra action – it does not create erection, it enhances it on the background of sexual stimulation.
Levitra effect is already seen 20 – 25 minutes after administration and this action time in most cases reaches up to 5 – 6 hours.
According to instruction on Canadian Health and Care Mall, Levitra is taken orally, regardless of meals, with a glass of water, not chewing the pill. Levitra may be combined with alcohol consumption (maximum – 100 grams of liquor), and also with vitamins, dietary supplements and a number of drugs. The drug is taken 30 – 60 minutes before anticipated sexual intercourse once a day. Its effect is maintained for 6 hours, for this reason, even if take Levitra 4 – 6 hours before sexual intercourse, erection will still be strong enough. According to some reviews, Levitra can cause stable erection even within 8 – 10 hours.
Instruction for Levitra recommends starting drug reception with initial dosage size of 10 mg, dosage adjustment for elderly patients is not required.
- In patients with mild hepatic insufficiency dosage adjustment is not required. In patients with moderate hepatic impairment initial dosage should be 5 mg a day. Further, depending on efficacy and treatment tolerability dosage can be increased to 10 mg and then to 20 mg.
- Patients with mild and moderate renal function impairment dosage adjustment is not required.
Maximum dose of Levitra daily should not exceed 20 mg. Such dosage is allowed in case of weakly pronounced effect after taking 10 mg of the drug, at diabetes or prostatectomy.
Due to individual characteristics of each body, as well as personal tolerability of Levitra suitable dosage often is determined by men themselves by trial and error method (of course within reasonable limits). But in any case, before taking Levitra it is extremely important to consult a doctor. Also, before taking this medication, you must carefully read instruction, make sure there are no contraindications, learn about possible side effects.
Symptoms: there were cases of receiving Levitra 80 mg 1 time/day and 40 mg 1 time/day for more than 4 weeks without developing serious adverse reactions. However, at the same time, when used in dosage of 40 mg 2 times/day there are marked back pains without signs of toxic effects on muscular and nervous system.
Treatment: symptomatic and supportive therapy. Since vardenafil strongly binds to plasma proteins and only a small amount of the drug is excreted by kidneys, dialysis unlikely to be efficient.
Instruction for use states that the drug should not be used at:
- hypersensitivity to main or auxiliary components of the drug;
- by women and children under the age of 16;
- by men suffering from severe cardiovascular diseases (arterial hypertension and hypotension, cardiac angina, and others);
- carcinogenic tumors.
Levitra should be taken only under medical supervision at:
- penis deformation;
- by patients who have recently had blood stroke, heart attack or other diseases after which sexual activity is prohibited;
- kidney diseases;
- liver insufficiency;
- ulcer exacerbation;
- low blood pressure;
- predisposition to hemorrhages;
- narrowing of aorta;
- left ventricle obstruction;
- predisposition to priapism;
- cavernous fibrosis;
- degenerative diseases of retina.
- drug effectiveness is not reduced at simultaneous intake with alcohol and / or fatty foods;
- strictly prohibited concomitant use of Levitra and other drugs of similar action (Viagra, Cialis);
- Levitra can not be used together with grapefruit or grapefruit juice;
- in patients with liver diseases result after taking Levitra is somewhat lower than in relatively healthy men.
In presence of other chronic diseases and regular intake of medications, before using Levitra you should undergo medical examination and get professional advice.
Effects on ability to operate vehicles and mechanisms
Before prescribing the drug to patients who are operate vehicles and work with mechanisms it is necessary to clarify their individual response to Levitra.
According Canadian HealthCare Mall data, Levitra is usually well tolerated, side effects are mild or moderate.
Central and peripheral nervous system:
- ≥10% – headache;
- ≥1% – dizziness;
- ≥0,1% – <1% – drowsiness;
- ≥0,01% – <0,1% – anxiety, fainting.
- ≥10% – hot flushes (sudden intermittent facial flushing, heat sensation);
- ≥0,1% – <1% – increased blood pressure, reduced blood pressure, orthostatic hypotension;
- ≥0,01% – <0,1% – cardiac angina, myocardial ischemia.
- ≥1% – <10% – dyspepsia, nausea;
- ≥0,1% – <1% – change in liver function tests (increased ALT, AST, GGT).
- ≥1% – <10% – congestive hyperemia of nasal mucosa (mucosal edema, rhinitis, rhinorrhea);
- ≥0,1% – <1% – shortness of breath, nasal hemorrhages;
- ≥0,01% – <0,1% – laryngeal edema.
Organs of vision:
- ≥0,1% – <1% – increased lacrimation, blurred vision;
- ≥0,01% – <0,1% – increased intraocular pressure.
- ≥0,1% – <1% – swelling of face, photosensitivity.
- ≥0,1% – <1% – myalgia, back pain, increased CPK;
- ≥0,01% – <0,1% – increased muscle tone. Reproductive system: >0,01% – <0,1% – prolonged or painful erection, priapism.
- ≥0,01% – <0,1% – hypersensitivity reactions.
There are rare postmarketing reports of cases of non-arteritic anterior ischemic optic neuropathy (NAAION), which leads to impaired vision, including permanent loss of vision associated in time with PDE-5 inhibitors intake, including Levitra, in patients many of which have related risk factors for development of this condition, such as anatomical defect of optic nerve, age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia and smoking. It not determined whether NAAION development is connected directly with PDE-5 inhibitors or with concomitant cardiovascular risk factors and anatomical defects or a combination of these factors or other causes.
Reported cases of visual disturbances, including temporary or permanent loss of vision, which are associated in time with taking PDE-5 inhibitors, including Levitra. It is not determined whether these cases are connected directly with PDE-5 inhibitors reception or concomitant cardiovascular risk factors or other causes.
These adverse reactions are completely harmless. They disappear quickly and do not require receiving additional medications.
Vardenafil is metabolized predominantly involving liver enzyme of P450 cytochrome system, namely CYP3A4, as well as with some participation of CYP3A5 and CYP2S isozymes. Inhibitors of these enzymes may reduce vardenafil clearance. With simultaneous use of Levitra with ketoconazole, itraconazole, indinavir and ritonavir (potent inhibitors of CYP3A4) you can expect significant increase of vardenafil concentrations in blood plasma.
Simultaneous application of cimetidine (400 mg 2 times/day), which is a non-specific inhibitor of P450 cytochrome system isoenzymes, does not affect AUC and Cmax of vardenafil (20 mg).
At concomitant use with Levitra (5 mg) erythromycin (500 mg 3 times/day), which is CYP3A4 inhibitor, causes increase in vardenafil AUC by 4 times (300%) and Cmax increase by 3 times (200%).
Ketoconazole (200 mg), as a potent CYP3A4 inhibitor, when used with Levitra (5 mg), causes increase in AUC of vardenafil by 10 times (900%) and Cmax – by 4 times (300%).
At simultaneous use of Levitra (10 mg) and HIV-protease inhibitor indinavir (800 mg 3 times/day), there is an increase in vardenafil AUC by 16 times (1500%) and Cmax – by 7 times (600%). 24 hours after administration, vardenafil concentration in blood plasma is about 4% of its Cmax.
At simultaneous use with Levitra (5 mg), ritonavir (600 mg 2 times/day) increases Cmax of vardenafil by 13 times and its total daily AUC rate – by 49 times. Interaction is explained by the fact that ritonavir, as a potent CYP2C9 and CYP3A4 inhibitor, blocks hepatic metabolism of vardenafil. Ritonavir significantly lengthens T1/2 of vardenafil to 25,7 hours.
In healthy volunteers, Levitra (10 mg) received 24 hours before administration of nitroglycerine (400 mcg sublingual) does not enhance its hypotensive effect, at dosage of 20 mg 1 – 4 hours before application of nitrates (400 mcg sublingual) enhances their hypotensive action, but when prescribed for 24 hours, hypotensive action enhancement does not occur.
Vardenafil (20 mg) does not alter AUC and Cmax parameters of glibenclamide (glyburide at dosage of 3,5 mg) at their joint use, and vice versa.
Pharmacokinetic and pharmacodynamics interaction (effect on prothrombin time and coagulation factors II, VII, X) is not observed at combination of vardenafil (20 mg) with warfarin (25 mg).
There has been no significant pharmacokinetic interaction between Levitra (20 mg) and nifedipine (30 mg or 60): Vardenafil in supine position causes additional reduction in systolic and diastolic blood pressure at average by 5,9 mm Hg and 5,2 mm Hg respectively.
Since it is known that alpha-blockers cause reduction in blood pressure, especially postural hypotension and syncope, question of interaction of alpha-blockers and Levitra when used together was carefully studied. Two studies were conducted on drug interactions in healthy volunteers with normal blood pressure receiving alpha-blockers tamsulosin or terazosin with rapid dosage increase to maximal or close to them within 14 days or less. After adding to this therapy Levitra, hypotension occurred in a significant number of study participants. Among those receiving terazosin, arterial hypotension (systolic blood pressure when standing below 85 mm Hg) developed more frequently if Levitra and terazosin were administered so as to reach Cmax coincidence in time than if Cmax diverged in time by 6 hours. These studies may have limited clinical relevance because they were conducted in healthy volunteers, and also after forced titration of doses (so that study participants failed to achieve stabilization of blood pressure in patients receiving alpha-blockers).
Studies of drug interactions of Levitra were also conducted in patients with benign prostatic hyperplasia (BPH) receiving stable doses of tamsulosin or terazosin. When appointing Levitra in doses of 5, 10 or 20 mg for patients who received stable doses of tamsulosin, additional decrease in blood pressure was not observed. At single reception of Levitra 5 mg and tamsulosin at dosage of 0,4 mg in 2 out of 21 patients orthostatic hypotension with drop in systolic blood pressure below 85 mm Hg was observed. When receiving Levitra 5 mg and tamsulosin with 6-hour interval, systolic orthostatic hypotension with drop in blood pressure less than 85 mm Hg also developed in 2 out of 21 patients. In subsequent study, at single reception of Levitra at dosage of 10 mg and 20 mg and tamsulosin at dosage of 0,4 mg and 0,8 mg, cases of orthostatic drop in systolic blood pressure below 85 mm Hg have not been registered. At single reception of Levitra 5 mg and terazosin at dosage of 5 mg or 10 mg, one out of 21 patients observed symptomatic postural hypotension. When receiving Levitra at dosage of 5 mg and terazosin with 6-hour interval, cases of blood pressure drop did not appear. The results should be taken into account when deciding on time of prescribing.
Combined prescription of Levitra and alpha-blocker is permissible only in presence of stable rates of blood pressure in patients receiving alpha-blockers, while Levitra should be administered in minimal recommended dosage of 5 mg. It is not recommended to take Levitra at the same time with alpha-blocker, with an exception of tamsulosin, reception of which can и combined with Levitra.
Concomitant use of digoxin (0,375 mg) and Levitra (20 mg) every other day for 14 days is not accompanied by drug interactions.
Single dose of Maalox (antacid, magnesium hydroxide / aluminum hydroxide) did not affect vardenafil AUC and Cmax.
Bioavailability of vardenafil (20 mg) was also not affected by its combination with histamine H2-receptor blockers – ranitidine (150 mg, 2 times/day) and cimetidine (400 mg, 2 times/day).
Levitra (10 mg and 20 mg) did not affect duration of hemorrhages when used as monotherapy and in combination with acetylsalicylic acid at low dosage (2 pill of 81 mg).
Levitra (20 mg) did not potentiate hypotensive effect of ethanol (0,5 g/kg of body weight), pharmacokinetics of vardenafil is not disturbed.
Aspirin, ACE inhibitors, beta-blockers, diuretics, and hypoglycemic agents (sulfonylureas and metformin), weak CYP3A4 inhibitors do not affect vardenafil pharmacokinetics.
Many people wonder: how do Levitra and alcohol consumption interact in the body? According to experts, these two substances have different origin and structure. Alcohol contained in similar beverages, has relaxing and harmful effects on body simultaneously. Levitra, as a drug for impotence, enhances erection at sexual stimulation. Taking large quantities of these means is not recommended, as there is a risk of occurrence of adverse effects.
However, many men due to various circumstances can sometimes take Levitra with alcohol. And in these cases they often talk about absence of significant unpleasant consequences for their organism. Is it true? Try to understand with Canadian HealthCare Mall.
Levitra and Alcohol Interactions
Levitra (vardenafil) is a drug that is prescribed to men with problems with erectile dysfunction. Regular intake of this medicine helps to enhance erection during sexual stimulation. Admission of Levitra is accompanied by rapid absorption and instant effect.
Reviews of men taking this drug are only positive. Also, many men say about absence of side effects, if after drinking alcohol (not more than 200 grams) take Levitra. But do not believe these prejudices and try to take medicine separately from alcohol-containing beverages.
According to doctors, not every man’s body is able to combine reception of Levitra with alcohol. Depending on individual specifics of the body, this combination can be dangerous, especially if amount of alcohol in the body is higher than permissible standards by several times. Moreover, drug composition includes enormous number of active compounds which may be contraindicated for some people or cause symptoms of hypersensitivity. Based on numerous studies conducted in many hospitals, it was found that Levitra drug should be taken after consultation with attending doctor.
Of course, this medicine has some adverse effects on liver structure at its cleavage. Vardenafil is able to influence negatively on liver cells, so it should be taken in prescribed dosages.
If the body is sober, vardenafil begins to actively influence relevant organs of urogenital system and stimulate them to work. As a result, a man in a short period of time is already starting to feel much better, he feels a burst of energy for further sexual activity.
In case of receiving Levitra, when the body is filled with a lot of ethanol, its metabolism in liver is delayed. As a result, action of the drug can be very slow and a man does not get desired effect on time. Therefore, you should not take these substances together, as one begins to act and the other remains in «waiting» stage.
Is it possible to take this drug by individuals, constantly consuming alcohol-containing beverages? Of course, such people have already disrupted normal operation of liver. Therefore, taking Levitra, even in small doses, a man begins to feel severe pains on right side. The reason for this is inability of liver cells at accelerated pace to begin processing received medication.
It is worth considering the fact that active ingredient of Levitra is intended to provide sober men with timely assistance, not alcoholics of the third stage. Therefore, very drunk men should not take medication in order to avoid causing harm to own body.
If such situation still appears, when it is necessary to combine alcohol with this medication, you must adhere to the following guidelines:
- do not get completely drunk;
- try to take medication at the beginning of sobering up stage;
- do wash the drug down with alcohol;
- do not take other pills.
If ignore this recommendation the following symptoms of overdose may occur:
In this case, you should drink as much fluids (water) as possible for early elimination of drug components from the body. If you feel worse seek help from medical institution.
At the moment, the most effective drugs for treatment of erectile dysfunction are Viagra, Cialis and Levitra. Very often people ask which of these drugs is the best, what to choose? The effect of each of these drugs is a little different from each other, and Canadian Health&Care Mall will try to provide you with basic information about these differences. All three drugs for the best effect require sexual excitement.
Viagra vs Cialis
In comparison – «which is better – Viagra or Cialis», in terms of compatibility with food, the situation is as follows: Viagra is recommended to be taken on an empty stomach, Cialis works equally well regardless of meal. Efficacy of Levitra may be slightly reduced after fatty foods consumption.
Viagra vs Levitra
To the next question – «which is better – Viagra or Levitra», referring to duration of action, the following answer can be given: Cialis has the greatest duration (36 hours), the second place in this comparison takes Levitra with its 10 – 12 hours and only the third place is given to Viagra, effect of which lasts 5 – 6 hours.
Advantage of all 3 drugs is small amount of side effects. The most common are hot flushes, headache, dizziness, nasal congestion. These side effects were observed in approximately 10% of patients who were taking one of the drugs. You should also know that individual characteristics of organism require using only one of these drugs. Action of Viagra is studied thoroughly, it is a powerful drug with a very short duration of action. Advantage of Cialis is its long time of exposure, which allows to have sexual intercourse at any time during drug action. Levitra is the safest drug that causes least number of side effects, its performance is not affected by food and drinks (that means that you can take Levitra with food or on an empty stomach).
From the above it can be concluded that in comparison Viagra vs Cialis vs Levitra there is no clearly defined leader, application of these drugs depends on individual characteristics of the body of each person. These means are medications and only doctor can prescribe or prohibit them. For one patient Viagra will be the best, while others prefer Levitra and Cialis. It is an individual choice.
We should not forget about bad habits, such as smoking, which can also disrupt potency.
Phosphodiesterase type 5 (PDE-5) inhibitors drugs are recommended as first-line agents for erectile dysfunction treatment. Currently, market presents four of them: sildenafil, udenafil, vardenafil (Levitra) and tadalafil. These compounds are available in the form of pills which are quickly absorbed in gastrointestinal tract. But creation of Levitra in the form of conventional coated pills has not stopped researchers, and a new form of the drug has been established – dissolving on the tongue (Levitra – orally dispersible tablets). This happened due to the fact that both patients and clinicians believe that rapid onset of action, greater bioavailability (compared to film-coated pills) and ease of use is an important attribute of oral erectile dysfunction drug therapy.
The pill dissolves in the mouth for a few seconds and does not require water which allows men to more flexibly manage their sexual activity, ensures easy administration and high efficiency.
16-week double-blind multicenter randomized placebo-controlled parallel-group study «POTENT I», conducted in 40 centers across Europe and South Africa, was aimed at studying efficacy and safety of a new preparation – generic Levitra. Participants were men aged 18 years and older, who suffered from erectile dysfunction for at least 6 months, who are in stable heterosexual relationships for at least 6 months and motivated for erectile dysfunction treatment. These men had at least two of four unsuccessful attempts to perform sexual intercourse on separate days. Evaluation of treatment quality was carried out according to IIEF criteria and sexual profile scale. Additionally there were assessed answers to questions about satisfaction with treatment and health state in general.
Out of 409 men surveyed (54,8% of those were aged 65 and older) 355 were included in the study. Patients were randomized in groups receiving Levitra (183 men) or placebo (172). Course duration was 12 weeks. Levitra therapy effect was significantly higher compared to placebo for all primary (IIEF-EF, SEP2, SEP3) and secondary efficacy parameters (p <0.0001). Frequency and type of side effects associated with Levitra were comparable to those in patients receiving Levitra pills with film coating.
At the same time in 35 centers in Australia, Canada, Mexico and the United States there was conducted a double-blind multicenter randomized placebo-controlled parallel-group study «POTENT II», devoted to study efficacy and safety of Levitra 10 mg in general population of men with erectile dysfunction. Men aged 18 years and older, suffering from erectile dysfunction were observed for 6 months, taking Levitra 10 mg «on demand»(169) or placebo (162). In each group about a half of subjects was 65-year-olds and older. Primary efficacy criterion was domain of erectile function, measured by IIEF-EF scale and sexual profile scales – SEP2 and SEP3. Levitra therapy was significantly more effective than placebo for all primary and secondary efficacy parameters (p <0,0001). According to researchers estimates, side effects were mainly mild to moderate severity and were similar in frequency and type to those in treatment with film-coated Levitra pills. Thus, as authors of the study say, treatment with Levitra 10 mg significantly improves erectile function, effective and well tolerated in broad population of men with erectile dysfunction.
M. Sanford confirms that Levitra in dosage equivalent to film-coated Levitra pill provides somewhat larger impact. Thus, two formulations are not interchangeable. Analyzing results of combined researches POTENT I and II, authors suggest that Levitra improved erectile function regardless of age, severity of the disease and presence or absence of concomitant diseases at minimally pronounced adverse reactions.
Thus, spectrum of used for erectile dysfunction treatment drugs has increased by innovative form – Levitra, which ensures rapid and necessary impact, high efficiency and safety. The drug is most comfortable for reception and therefore preferable to previously manufactured PDE-5 inhibitors.
For men, the most important requirements for a drug for erectile dysfunction treatment are (in descending order of importance): «acts every time», «increases penis elasticity», «fast action and simple use», «gives self-confidence in sexual abilities». An important consequence of taking the pill has to be not only «better and longer sex», but spontaneity and flexibility of sexual life.
«ACCEPTANCE» study evaluated degree of preference of PDE-5 inhibitors pills form, including pills, dissolving in oral cavity, among patients suffering from erectile dysfunction. Almost all men with erectile dysfunction, who participated in the study (not using PDE-5 inhibitors – 95%, use now – 92%, used in the past – 95%) got positive opinion about Levitra in the form of pills, dissolving in mouth, mainly due to ease of use. When men, suffering from erectile dysfunction, were asked about what they particularly liked about the product, certain positive characteristics were named combination of product features (rapid dissolution and method of receiving / form) and convenience (no need to drink water / liquid, simple and easy reception). According to the study, most men said that they would be likely to refuse from their current drugs for erectile dysfunction treatment in favor of pills dissolving in the mouth. There are also other factors that determine patient’s adherence to orally dispersible tablets (including Levitra), in particular disorders of swallowing, inconvenience of swallowing large quantities of liquid or nausea. Dysphagia or difficulty with swallowing periodically occur in 35% of population under influence of any factor associated with aging or certain medical conditions, such as cerebral vessels.
Thus, original form of Levitra was developed, with mint flavor (menthol flavor due additives), able to dissolve in the mouth during several seconds without need to wash it down with water. Levitra can be taken with or without food, as it does not interact with products, including those containing large amounts of fat and calories. Concomitant use of Levitra and food does not affect pharmacokinetics and pharmacodynamics. The new form is presented in stylish black color package of credit card size with special elegant design and easy to use.
Levitra – is the first and the only PDE-5 inhibitor in such an innovative form available on Canadian Health and Care Mall.
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