Generic Cialis (Tadalafil)

1. Generic Version of the Drug
2. Composition
3. Pharmacology
4. How to take Cialis?
5. Mechanism of Action
6. What Should You Know about Generic Drug?
7. Side Effects
8. Contraindications
9. Overdose
10. Interactions with Other Medications
11. Special Instructions
12. Unique Properties of the Drug
13. The History of Cialis
14. Cialis for Women
15. Cialis vs Viagra vs Levitra
16. Cialis for BHP
17. FAQs about Canadian Cialis
18. Cialis and Alcohol

All You Need To Know About Cialis

Generic Version of the Drug

Generic Cialis is a contemporary medication to fight erectile dysfunction, the main property of which – prolonged effect. The drug lasts up to 48 hours under appropriate conditions.

The main ingredient of the drug is Tadalafil. Due to this substance, the generic preparation provides long-lasting and high-quality erection with even the most severe sexual health problems.

This generic drug has passed all clinical research and also received FDA approval, which implies direct confirmation of high quality, safety, and effectiveness.

Trade Name	Cialis
Pharmacological Group	PDE5 inhibitor (phosphodiesterase-5)
Active Ingredient	Tadalafil
Pharmacological Form	almond-shaped, film-covered pills with oval points

Composition

The main active ingredient of Cialis is Tadalafil. This component has an effect on erectile function and is not harmful to male health. When the drug is taken in the recommended dosage, substance does not cause allergic reactions and any other side effects.

Tadalafil acts directly on penile blood vessels, relaxing muscles, causing a strong erection.

Generic Cialis includes the following additive agents:

• talc;
• lactose;
• magnesium stearate;
• sodium lauryl sulfate.

These substances are safe for the male body and are not addictive. The remedy is produced in the form of film-coated pills. Each capsule formulation contains 20 mg of tadalafil (a daily dosage).

Pharmacology

Tadalafil belongs to reversible PDE-5 inhibitors and has a selective effect on the reproductive system. Action mechanism is similar to the whole group of PDE5 drugs. Once sexual excitement begins, nitric oxide releases starting hemodynamic erection appearance process.

The drug increases cGMP level, which directly affects corpora cavernosa smooth muscles relaxation and increases blood flow to it, which causes persistent erection and willingness to have sexual intercourse during 36 hours. Tadalafil is considered the most active enzyme of all PDE5 inhibitors belonging to this group, so it is much more productively from similar drugs for potency.

How to take Cialis?

The pill should be taken 30-40 minutes before planned sexual intercourse. The initial recommended dose of Cialis is 10 mg. If you conduct infrequent sex life, it is better to take a 20 mg pill.

20 mg is the maximum daily dose. It should also be noted that presence of serious problems with kidneys, liver and cardiovascular system reduces dose up to 5 mg. In this case, you will protect yourself from possible side effects.

Mechanism of Action

Tadalafil influences penile smooth muscles resulting in increased blood flow and ensures erection. The special formula allows you to keep effect duration for 48 hours.

What Should You Know about Generic Drug?

Generics are produced by different manufacturers, with a variety of forms, dosages, contraindications, side effects.

Therefore, to make the right choice, get acquainted with the information given by Canadian Health and Care Mall.

About Generic Manufacturers

Generics’ efficiency and safety depend on manufacturer’s reliability. If company’s name is widely known in the pharmaceutical market if it has established itself as a reliable over many years, one can not doubt its products quality.

Canadian Cialis is produced by known and trusted companies only:

• Sunrise Remedies Pvt. Ltd.;
• Delta Enterprises;
• Ajanta Pharma Ltd.;
• Cipla;
• Combitic Global.

You can buy generic Cialis online and get one more enjoyable advantage: this generic medication has a variety of dosages. This is useful for selecting optimal dose in each case. You can buy just the one that best suits you. The original drug is available in tablets containing only 5 and 20 mg of tadalafil. In Canadian Pharmacy, you will find Cialis dosages of 2.5, 5, 10, 20, 40, 60 mg.

2.5 and 5 mg are prophylactic doses for maintenance of male health. 20 mg is recommended daily dose for men who suffer from erectile dysfunction. The rest of dosage – increased ones. Their use can only be prescribed by a doctor.

Pharmaceutical Forms

In our online store you will be able to choose this generic drug in any convenient for you form: tablets, absorbing and chewing pills (Soft), gel (jelly) capsules with liquid active substance and tablet with double action (two active substances).

If you prefer to simply swallow medicine and forget about its existence, you may purchase tablets. A doctor will help you to choose correct dosage. Their effect begins after about half an hour after you take it.

Indications for Use

All medications containing active substance Tadalafil, are intended for men with erectile dysfunction of any severity and occurred for any reason. They can also be used for prevention of failure during sexual intercourse when it can cause increased tension and excitement. A small dosing regimen can be used to maintain sexy men in tone as much as possible. But, medication should be taken no more than once per day.

Side Effects

Side effects of Cialis are usually mild to moderate in severity and decrease when you prolong the course.

Common side effects:

• The most frequent: a headache (11%), dyspepsia (7%);
• Possible: pain, back pain, myalgia, nasal congestion, flushing;
• Rare: eyelids swelling, eye pain, conjunctival hyperemia, dizziness;
• Very rare: hypersensitivity reactions (which include rash, hives, and face swelling, Stevens-Johnson syndrome and exfoliative dermatitis), hypotension (in patients who are already taking antihypertensive agents), hypertension and syncope, abdominal pain and gastroesophageal reflux, hyperhidrosis (excessive sweating), priapism, erection retention, blurred vision, anterior ischemic optic neuropathy, retinal vein occlusion, sight disturbance;
• Cardiovascular system: in patients with cardiovascular risk factors – myocardial infarction, sudden cardiac arrest, blood stroke, chest pain, palpitations, and tachycardia, but it is impossible to pinpoint whether these phenomena are connected directly with tadalafil application, with sexual stimulation, or combination of these or other factors.

Contraindications

Cialis cannot be taken by boys under 18, women and men with an allergy to any ingredient of the drug. Do not use this remedy if you are hypersensitive to tadalafil because it may cause serious body poisoning and health problems.

This PDE-5 inhibitor should not be taken in:

• chronic heart diseases;
• unstable angina and high blood pressure;
• renal or hepatic impairment;
• penile trauma and other inflammatory processes.

Tadalafil is not combined with medications, which contain:

• nitrates;
• alpha-blockers;
• nitrogen donators.

It is also contraindicated in men means for whom sexual activity is prohibited.

Among them, there may be people suffering from acute heart failure and uncontrolled arrhythmia.

Overdose

The maximum daily dose of Cialis is 40 mg (two tablets). However, to use such a tadalafil quantity is possible only after consultation with a doctor. To avoid overdose, it is recommended to use the standard daily dose – 20 mg.

Tadalafil overdose causes increased expression of side effects and a sharp deterioration in patient’s health state. Having felt the first overdose symptoms, the patient should seek medical advice immediately.

Interactions with Other Medications

Some drugs may affect the action of Cialis:

Tadalafil is mainly metabolized by a CYP3A4 enzyme. Selective CYP3A4 inhibitor -ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Despite the fact that specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, and inhibitors of CYP3A4, such as itraconazole, and erythromycin, increase Cialis activity.

Simultaneous antacid (magnesium hydroxide/aluminum hydroxide) and tadalafil intake reduce absorption rate of the latter without changing AUC.

Increased gastric pH as a result of receiving blocker nizatidine histamine H2-receptors, has no effect on tadalafil pharmacokinetics.

Effect of Tadalafil on other drugs:

Tadalafil enhances hypotensive nitrates effect. It happens due to an additive effect of nitrates and tadalafil on nitric oxide and cGMP metabolism. Therefore, Cialis appointment is contraindicated during treatment with nitrates.

Tadalafil has no clinically significant effect on drugs clearance that is metabolized with the participation of cytochrome P450 isoenzymes.

Studies have confirmed that tadalafil does not inhibit or induce isozymes of CYP3A4, CYP1A2, CYP2D6, CYP2E1, and CYP2C9.

Tadalafil has no clinically significant effect on the pharmacokinetics of S-and R-warfarin. Tadalafil does not affect warfarin action on prothrombin time.

Thet ED drug does not increase bleeding duration on a background of acetylsalicylic acid.

Cialis does not show clinically significant interaction with major classes of antihypertensive agents including:

• calcium channel blockers (amlodipine);
• ACE inhibitors (enalapril);
• beta blockers (metoprolol);
• alpha-blockers;
• thiazide diuretics (bendrofluazide);
• angiotensin II receptor blockers.

There are no differences in adverse events in patients taking this ED drug with or without antihypertensive drugs. There was no effect of a single dose on a concentration of ethanol in blood, the effect of ethanol on cognitive function and blood pressure. Furthermore, no changes were observed on tadalafil concentration in blood in 3 hr after administration in combination with ethanol.

Canadian Cialis has no clinically meaningful effect on theophylline pharmacokinetics and pharmacodynamics.

Special Instructions

Since there are no data of controlled clinical studies on Cialis safety and efficiency in patients with renal severe insufficiency (creatinine clearance <= 30 mL/min) and severe hepatic impairment, drug use in these patients should be carried out with caution and only when absolutely necessary. Treatment of patients with renal moderate insufficiency (creatinine clearance 31-50 mL/min) was provoked back pain compared to patients with mild renal insufficiency (creatinine clearance 51-80 ml/min) or in healthy volunteers. Patients with creatinine clearance <= 50 ml/min, the drug should be used with caution.

Sexual activity is a potential risk for patients with cardiovascular disease. Therefore, erectile dysfunction treatment with Cialis is contraindicated in men with heart disease who are not recommended to live a sexual life.

It is necessary to take into account potential risk of complications during sexual activity in patients with cardiovascular system diseases:

• myocardial infarction within 90 days prior;
• unstable angina or angina occurring during sexual intercourse;
• chronic heart failure (II functional class and higher NYHA classification), which developed during the last 6 months;
• uncontrolled heart rhythm disorder;
• hypotension (blood pressure less than 90/50 mm Hg), or uncontrolled hypertension;
• stroke, myocardial within the last 6 months.

Cialis should be used with caution in patients with a predisposition to priapism (eg, in sickle-cell anemia, multiple myeloma or leukemia), or in patients with anatomical penile deformation (for example, angulation, cavernous fibrosis or Peyronie’s disease).

The patient should be informed of the need for immediate treatment when an erection lasts for 4 hours or more. Untimely priapism treatment causes penile tissues damage, as a result of this long-term potency loss may occur.

Unique Properties of the Drug

Medical experts guarantee Cialis reliability.

It is most effective if erectile dysfunction occurred in the background of psychological causes, physical causes, psychosomatic causes.

One of the most important characteristics that explain the popularity of this drug is high safety and excellent tolerability. The list of Cialis contraindications is significantly shorter than that of sildenafil. And side effects – rather exceptional phenomenon.

If you’re going to forget about problems in sex for a long time and want to spend it at your leisure, medicine can help you do this. Why? Tadalafil effect lasts up to 36 hours. All this time, you can be quite sure that there are no failures during intercourse.

Those who are impatient or those who need to get results faster, it is also better to buy Cialis online at Canadian Pharmacy. It takes effect within half an hour.

Another great advantage of this remedy is that it can be used together with small doses of alcohol and low-fat food.

In this case, note that large doses of alcohol may cause severe side effects.

The History of Cialis

This drug was developed by Glaxo Wellcome (today GlaxoSmithKline) in a partnership between Glaxo and ICOS, which began in August 1991. In 1993, Bothell, Washington saw how biotechnology company ICOS Corporation began studying compound IC351, the inhibitor of phosphodiesterase type 5 enzyme (PDE-5). In 1994, Pfizer researchers explored that sildenafil (future – Viagra), which also inhibits a PDE-5 enzyme, caused penile erection in men participating in a clinical trial. Although ICOS scientists were not testing compound IC351 for ED treatment, they recognized its potential usefulness in this disorder treatment. Soon, in 1994, ICOS obtained a patent for compound IC351 and in 1995 the first phase of clinical trials started.

In 1997, Phase 2 was started involving men suffering from erectile dysfunction, then tests have progressed to phase 3, after completion of which possible FDA approval was obtained. Although Glaxo had an agreement with ICOS to distribute profits 50/50 from Cialis sale, resulting from collaboration, in 1996 Glaxo let agreement expire, because the development of this drug was not the key to the company’s main markets’ aims.

In 1998, ICOS Corporation and Eli Lilly and Company established Lilly ICOS, LLC, a joint venture to further development and commercializing of tadalafil as erectile dysfunction treatment. Two years later, Lilly ICOS, LLC filed a new application with FDA on the IC351 compound (under tadalafil generic name and brand name).

In May 2002, Lilly ICOS on a report in American Urological Association reported that clinical trials have shown that tadalafil was effective up to 36 hours, and a year later, FDA approved tadalafil as ED drug. One advantage – Cialis vs Viagra vs Levitra is its 17.5-hour half-life.

In 2007, Eli Lilly and Company bought ICOS Corporation for $ 2.3 billion.

October 6, 2011, FDA approved tadalafil as the treatment for benign prostatic hyperplasia (BPH). FDA also approved tadalafil for the treatment of BPH and erectile dysfunction (ED) at the same time.

Cialis for Women

Cialis can be used by women after consultation with a doctor-sexologist and making analyzes to determine hormonal balance.

With a decrease in hormone estrogen associated with aging and menopause, women experience some changes in sexual function. Such changes include:

• reducing production of vaginal lubrication;
• decreased genital sensation.
• In addition, studies show that low levels of male hormone – testosterone also reduces:
• sexual excitement;
• libido;
• orgasm.

The study is conducted relating to advantages of hormones and ED drugs for female sexual problems.

Women can not independently appoint man’s solutions to improve erectile function. It can lead to serious health problems.

Female Cialis: Reviews of Patients and Physicians

Some women in forums and reviews say about women’s tadalafil that this remedy really helps. Perhaps it may be connected to improved blood flow to genitals in patients with impaired blood circulation.

However, a sexual response in women is much more complex when comparing to men. Women are very attached to emotions, as well as many chemical and hormonal reactions. Therefore, only gynecologist or sexologist can assign female tadalafil-based remedy or its analogs, such as female Viagra, after studying results of analysis of hormones level.

Question about whether tadalafil can help women with sexual problems and problems with excitement remain controversial. Currently, there is no information available to determine whether this drug helps women with sexual desire disorders.

Officially, the manufacturer does not claim that Cialis can help women achieve sexual excitement because it helps men only. The manufacturer points out that this drug does not help to increase sexual desire. This medication works by preventing enzyme phosphodiesterase type 5 action, which is responsible for regulating erection. Due to tadalafil action, penile tissues are filled with blood and penis is retained in “combat” position. In principle, this mechanism of action is extremely effective in case of male physiology. But it is unknown whether this enzyme plays a role in female excitement.

Cialis vs Viagra vs Levitra

Viagra, Cialis, and Levitra are essential drugs for erectile dysfunction treatment. The drug Viagra is time-tested (sildenafil citrate, active ingredient). Viagra was created over 25 years ago. High scientific evidence base and extensive clinical trials of Viagra are basic and not the only advantage over the other drugs. Levitra (Vardena is an active ingredient) – a relative newcomer in the pharmaceutical market. Cialis (tadalafil – active ingredient) appeared in 2003. All three drugs perform on corpus cavernosum, contributing to its blood supply and causing a persistent erection. The mechanism of action is the same.

The main differences between these PDE-5 inhibitors:

• Duration. Viagra works up to 6 hours, Levitra – 10, and Cialis up to 36 hours (it is called “weekend drug”). The latter is more comfortable in use, as there is no problem that its action suddenly ends;
• Time ingestion. Levitra is the leader here, it starts to be active 15 minutes after ingestion. Viagra takes effect in 30-45 minutes. Tadalafil-based remedies can be taken 30 minutes before sexual intercourse;
• Compatibility with meal and alcohol. The medicinal Viagra effect is greatly reduced when receiving abundant and fatty foods, so it is always taken on an empty stomach. Simultaneous use of alcohol can weaken Viagra effect. On therapeutic Levitra and Cialis action meal (especially fat) and alcohol – have almost no effect;
• Half-life. This indicator is important for people suffering from cardiovascular and renal diseases. The use of these drugs in conjunction with nitroglycerin – dangerous to life! The smallest half-life (3-5 hours.) Viagra has. Levitra half-life is up to 6 hours, Cialis – 18 hours, it is contraindicated (absolutely) to patients taking nitroglycerin;
• Effect on color perception. Viagra causes a change of color perception. Cialis and Levitra do not have such side effect;
• In diabetes, metabolism is always in disorder. Drugs absorption into bloodstream deteriorates. By virtue, Levitra is superior to Viagra and Cialis, so its effectiveness in diabetics is higher. Tadalafil is safer for diabetics, but it works a little weaker;
• Dosage. Viagra contains 50 or 100 mg of active substance. The other two PDE-5 inhibitors contain 20 mg of active ingredient;
• Side effects of drugs are the same and are quite rare. Levitra should not be used in case of penile deformation. Tadalafil is more secure. In a failed sexual intercourse, this drug causes less negative feelings.The problem of drug choice depends on many factors. For elderly patients, Tadalafil is preferable. When erectile dysfunction of psychogenic nature – Viagra is mandatory. When metabolic disorders – Levitra. Correctly select product – it is the most important step in erectile dysfunction treatment.
• The problem of drug choice depends on many factors. For elderly patients, Tadalafil is preferable. When erectile dysfunction of psychogenic nature – Viagra is mandatory. When metabolic disorders – Levitra. Correctly select product – it is the most important step in erectile dysfunction treatment.

Cialis for BHP

Tadalafil is approved in Europe for prostate adenoma treatment.

This preparation obtained approval of new indications for use. The European Commission has authorized Cialis use for treatment of signs and symptoms of benign prostatic hyperplasia – BPH. Initially, the drug was approved by European regulators in 2002 for erectile dysfunction treatment.

Due to this approval, tadalafil was the only drug in Europe for men suffering from erectile dysfunction and BPH. Therefore, approval of a single product for both indications in patients is a new successful treatment option.

FDA issued a registration certificate of Cialis (tadalafil) in the last year, approved it as a treatment for symptoms of benign prostatic hyperplasia, as well as for use in men with erectile dysfunction and BPH. Also, the drug has already been approved in Canada, Brazil, Russia, Israel and other countries for the same application.

FAQs about Canadian Cialis

Q: How does this drug affect libido?

It is important to understand that this drug, like all generics, is not a means that artificially increases libido. So Cialis will be effective only if there is sexual partner (male or female) and sexual excitement.

Q: Cialis and severe form of erectile dysfunction

The drug is effective in any erectile function violations.

Q: Action of this drug on sperm production

Tadalafil is is absolutely safe and does not disturb male reproductive function, maintains quality and quantity of sperm, all its indicators are normal.

Q: How long and often can you take these pills?

The drug can be taken at will, depending on nature and temperament. However, to avoid overdose, it is not recommended to take the drug more than once a day.

Q: Does half of the pill work?

To get the most tangible tadalafil effect, a drug is recommended for intake in its usual dosage – 20 mg.

Q: Women and Cialis

For female population, it is created special medications to solve problems with sexual excitement, such as female Viagra. Cialis is designed exclusively for men.

Q: Tadalafil and diabetes

This drug is designed specifically for people who have health problems as a whole. The drug safety allows you to take it in case of diabetics, with very effective results.

Q: I take Cialis, but I do not feel the effect, will I achieve an erection?

It depends on what you are doing. If you sit at a computer, or just read a book, you waste time waiting for signs of sexual excitement. You must see and feel natural source, ie a sexual partner. Here it is necessary to understand that drug has a kind of “rejuvenating effect”, to remember fullness of the most vivid satisfaction from sexual intercourse.

Cialis and Alcohol

Cialis and alcohol can be used together, but only by adhering to certain rules. More information about the interaction of alcohol and tadalafil are presented below.

It’s no secret that sexual desire and attraction increases many times when consuming alcohol. However, alcohol consumption, especially in large quantities, greatly reduces sexual function in men with a normal and even healthy erection, not to mention men with potency disorder.

Cialis is a popular and spectacular means to increase erectile function, which for many years used by men of all ages to solve potency disorder and to increase erectile function. Often there are situations (birthday, stag, etc.) when you want to combine this drug with alcohol.

According to clinical research of company Eli Lilly, Cialis active ingredient – Tadalafil had no significant effect on the level of alcohol in the body, even as alcohol does not affect the concentration of tadalafil taken.

In clinical studies, patients who consumed alcohol in a dose 0.7 g / kg (approximately 180 grams of vodka /80 kg body weight) in combination with tadalafil 10 mg or 20 mg, blood pressure was decreased more when using only alcohol. However, the drug does not cause severe side effects and gain a significant reduction in blood pressure.

In a case when patients take 20 mg of the drug with a low dose of alcohol, 0.6 g / kg (100-120 gm of vodka), a decrease in blood pressure was observed, and dizziness may take place.

What is specified in the instructions about Cialis and alcohol interaction?

The instructions for use contains the following recommendation:

• Do not drink large amounts of alcohol, for example, no more than 5 glasses of wine or 5 servings of whiskey.
• Excessive alcohol dose is likely to increase side effects: dizziness, headache, or increased heart rate.

Use of Cialis with large doses of alcohol can also cause hypotension (decrease in blood pressure by more than 20%).

The action of strong alcohol and ED preparation is quite similar – both are vasodilators, and their combination increases blood flow and heart rate, and lowers blood pressure.

What to do if I often take Cialis with alcohol?

If you want to drink alcohol frequently and/or in large quantities, while also taking tadalafil-based remedies, then you definitely need to consult a doctor.

He will prescribe the correct dosage of the drug and alcohol, following which you will not cause more harm to the body and at the same time preserve the drug effectiveness. Perhaps you can find other contraindications to consuming alcohol.

Recommendations for combining Cialis and alcohol

Small doses of alcohol taken with the PDE-5 inhibitor will not cause any problems for most men. Do not abuse alcohol or limit its reception, when you need to take the pill.

Remember that large doses of alcohol not only reduce the effect of the drug and enhances side effects but also have a very negative effect on erection and can lead to potency disorders.

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