List of Questions
What is generic Cialis?
Generic Cialis has a high efficiency, which not only improves erection but also helps patient recover naturalness of sexual relations. The drug is reliable, efficient, easy to use and safe, it restores normal sexual life for patients suffering from erectile dysfunction, freeing them from constant thoughts about treatment.
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How does it work? Is it a sexual stimulant?
NO, IT IS NOT a STIMULANT. For a successful result, you need to be sexually excited. Everything happens naturally. The remedy works precisely when it is necessary, but not when it is not needed. The generic drug has a positive effect on the following manifestations and consequences of erectile dysfunction:
- it is generally possible to achieve an erection sufficient for sexual intercourse;
- ability to maintain an erection during intercourse;
- getting satisfaction from sexual intercourse;
- positive emotions;
- satisfaction of good erection;
- confidence to achieve and maintain an erection;
- partner satisfaction.
What is the mechanism of action?
Generic Cialis (Tadalafil) – effective, reversible inhibitor selectively acting on phosphodiesterase 5 (PDE5). The central role is played by penile corpus cavernosum smooth muscle cells relaxation, which is locally triggered by:
- acetylcholine;
- nitric oxide;
- other physiological agents.
Acetylcholine is produced by neurons an of the parasympathetic nervous system, and nitrogen oxide is released by non-adrenergic, non-cholinergic neurons and endothelial cells. Net effect – suppression state of sympathetic nervous system stimulation or alpha, which causes contraction of smooth muscle cells.
Guanosine monophosphate (cGMP) and PDE5 play important role in normal erectile function causing arteries expansion, resulting in blood flow increase to erectile tissues. Blood vessels in cavernous bodies fill with blood, which causes a decrease in blood outflow from the penis, creating blood pressure gradient – erection. The enzyme PDE5 causes a decrease the in the level of cGMP and terminates erection. Tadalafil inhibits the action of PDE5, thus delaying the drop in cGMP level. Asa result, cGMP level in cavernous bodies allows men with erectile dysfunction have a normal erection.
How effective is generic Cialis?
The drug, which is taken when required, up to once a day, improves erectile function in most men suffering from erectile dysfunction of any severity.
Does the product cope with severe erectile dysfunction?
Yes, it does. In clinical trials, 81% of patients taking Cialis generic in tablets of 20 mg resulted in improved erectile function. The study included patients with varying severity of erectile dysfunction, from mild to severe.
How fast Cialis starts to work and how long does it last?
In some men, the drug takes effect within 16 minutes. For most patients, this time is 30 minutes. But remember, without sexual stimulation effect does not occur. The action of one pill lasts almost 36 hours after ingestion.
I heard that this preparation is banned in cardiac diseases. Is it true?
Sexual activity is a risk in presence of cardiac diseases, so it is strongly recommended to consult a doctor before using this generic remedy.
How often can I take Cialis?
The recommended dose is 20 mg. The maximum recommended the frequency of admission – once a day.
What are contraindications?
Main contraindications are a simultaneous reception of nitrates in angina pectoris, and hypersensitivity to drug and its components.
Which type of a doctor may prescribe generic ED pills?
Physician, urologist, sexologist, andrologist, endocrinologist, and cardiologist may prescribe Cialis generic for you.
If generic Cialis is safe and effective, why not to sell it without a prescription?
Yes, clinical trials have demonstrated the drug safety. Moreover, Canadian Health and Care Mall sells generic ED pills over the counter but our specialists recommend to consult a doctor to determine appropriate for your dosage.
How does Cialis interact with other drugs?
In clinical trials, it was found insignificant interaction with other drugs, or its absence. However, an exception to this rule are nitrates, which are mainly used in cardiac disease treatment. Therefore, this generic ED medication is contraindicated in patients receiving treatment with nitrates. The danger is a possible significant drop in blood pressure – hypotension.
Once again, Canadian Pharmacy Mall pays attention that patients taking any form of nitrates should not take Cialis whether it is generic or not. If a patient is taking this drug while taking any medication based on nitrates or light drugs (recreational drug) containing nitrates, your blood pressure may drop to dangerous level. Many medications prescribed for the treatment of sternum pain, caused by heart disease contain nitrates.
These drugs include:
- nitroglycerin (sprays, ointments, patches or pastes, and tablets for dissolution under the tongue);
- isosorbide mononitrate;
- dinitrate (tablets that are swallowed, chewed, or held under the tongue).
Certain recreational drugs such as amyl nitrate or nitrite ( “poppers”) also contain nitrates. This list is far from complete so it is important to ask patient whether he takes nitrates or preparations containing them.
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