What is Amoxicillin?
Amoxicillin is an antibiotic which refers to the group of penicillins and possesses a broad spectrum of action.
The antibiotic inhibits the activity of harmful bacteria in the human body
(staphylococcus, streptococcus, E. coli and many others). Amoxicillin kills these
microbes, acting on the walls of their cells. However, the drug is destroyed in the
body under the influence of the enzyme penicillinase (beta-lactamase). Not all
bacteria are sensitive to the drug; there are bacteria that remain insensitive to
this antibiotic. Get more details about what
Amoxicillin is…
Generic Product
Amoxicillin is a generic product – a drug with proven pharmaceutical, biological and therapeutic equivalence to the original preparation. That is, the generic drug has the same composition of active ingredients, dosage form, and effectiveness as the original drug, but has no patent protection.
Often generic drugs differ from the original one by secondary components. Generic drugs enter the market after the expiry of patent protection for the original drug.
The necessary requirement for the sale of generic drugs is a proven pharmaceutical,
biological and therapeutic equivalence to the original. Read
more about generic Amoxicillin…
Dosage and Instructions for Use
- Canadian Pharmacy Mall sells 4 dosages of Amoxicillin: 250 mg, 500 mg, 650 mg, 1000 mg;
- The medication is taken orally. Food does not affect the absorption of the drug from the gastrointestinal tract, that is why it is possible to take the generic before or after meals – at any convenient time for the patient;
- The usual dosage for adults and children over 12 (with a body weight over 40 kg) is 500 mg 3 times a day;
- Each case is individual and the dose should be determined by the physician. If necessary (in case of severe disease), the dosage may be increased up to 750-1000 mg 3 times a day or even more;
- The maximum permissible daily dose for adults is 6 g;
- Some diseases require the outsize dosage;
- After the disappearance of the external signs of any disease, treatment with this antibiotic should be continued for 2-3 days to avoid recurrence of the infection. The average treatment course is 5 – 12 days. See more details about Amoxicillin dosage and instructions…
Side Effects
If Amoxicillin is taken incorrectly, a person may experience side effects:
- Allergic reactions (allergic rhinitis, conjunctivitis, urticaria; in rare cases – more severe allergy up to anaphylactic shock);
- The negative impact on the digestive organs (dysbiosis, nausea, vomiting, taste disturbance, stomatitis, glossitis, diarrhea, etc.);
- Effects on the nervous system (insomnia, agitation, anxiety, depression, headaches, dizziness, convulsions).
Side effects, especially relating to the nervous system, appear rarely. See Amoxicillin
side effects in detail…
Contraindications
- Infectious mononucleosis, lymphatic leukemia, severe gastrointestinal infection accompanied by diarrhea or vomiting, respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and/or cephalosporins;
- For use in combination with metronidazole: nervous system disorders; blood flow violation, lymphatic leukemia, infectious mononucleosis; hypersensitivity to nitroimidazole derivatives;
- For use in combination with clavulanic acid: possible liver dysfunction and jaundice. See a full list of Amoxicillin contraindications…
Interactions
- Amoxicillin reduces the effect of estrogen contraceptive drugs, reduces clearance and increases the toxicity of methotrexate;
- The generic drug increases the absorption of digoxin;
- The excretion of this antibiotic is slowed by probenecid, sulfinpyrazone, aspirin, indomethacin, oxyphenbutazone, phenylbutazone and others drugs that suppress the tubular secretion;
- Antibacterial activity is decreased by bacteriostatic chemotherapeutic agents and antacids, increased – by aminoglycosides and metronidazole. Read on more Amoxicillin interactions…
Amoxicillin and Alcohol
This antibiotic is NOT compatible with alcohol. The combination of these substances
can cause a severe allergic reaction and even the patient’s death. In
addition, both alcohol and Amoxicillin pills have a strong toxic effect on the
liver. The work of this organ may be paralyzed. Canadian Health and Care Mall
advises abstaining from alcoholic beverages for 7-10 days even after the end of
treatment with this generic medication.
Amoxicillin for Children
This drug is widely used in the treatment of children of different ages, including
newborns and premature babies. Children under 5 years of age usually take this
antibiotic in the form of a suspension. Babies usually receive these pills on an
outpatient basis, ie. in the treatment of mild forms of various diseases, most often
– in case of SARS with bacterial complications, such as acute otitis,
pharyngitis, tracheitis, bronchitis, skin infections, mild forms of intestinal
infections. Sometimes – for the treatment of gastric ulcer and 12 duodenal
ulcers, as well as for the prevention of recurrence of the disease. There are
contraindications for use. It’s necessary to pay a special attention to
children with bleeding disorders and impaired renal function when treated with these
tablets. More
details about Amoxicillin for children…
Amoxicillin during Pregnancy
Amoxicillin during pregnancy is prescribed only if the anticipated benefits of the
drug to the mother outweigh the possibility of harm to the fetus. Although there are
no cases of the negative impact of this antibiotic on pregnancy and childbirth, the
qualified studies on this topic have not been conducted. Thus, doctors prefer not to
take the risk. The generic product is contraindicated during the breastfeeding
period: the drug penetrates into breast milk and may cause an allergic reaction of
an infant or a violation of intestinal microflora.
Additional Information
Read special instructions and additional information to avoid complications and get the maximum benefit from the antibiotic.
- Patients prone to allergic reactions take these tablets with caution;
- The combination with metronidazole is not recommended for use in patients under 18;
- The drug should not be used in treatment of liver diseases;
- It is not recommended to drink alcohol during combined therapy with metronidazole;
- There is NO data on the effect of Amoxicillin on transport management capacity or machinery operating.