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Mild interactions of Amoxicillin include:

  • amiloride.
  • aztreonam.
  • azithromycin.
  • erythromycin base.
  • clarithromycin.
  • chloramphenicol.
  • erythromycin lactobionate.
  • erythromycin ethylsuccinate, and others.

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Dangerous interactions of Amoxicillin include:

  • allopurinol – may lead to allergic skin reactions;
  • digoxin – may increase its absorbability against background therapy when used with this antibiotic;
  • anticoagulants – can increase the chance of bleeding due to the prolonged prothrombin time. The joint appliance of anticoagulants and Amoxicillin requires homeostatic indicators constant monitoring;
  • probenecid – suppresses amoxicillin clearance through the kidneys and leads to an increase in the concentration of generic Amoxicillin in blood;
  • other antibiotics from Canadian HealthCare Mall – there is a possibility of antagonism action when used in combination with other bacteriostatic agents: macrolides, tetracyclines, sulfonamides;
  • methotrexate – may increase the degree of toxicity what may result in competitive inhibition of renal tubular secretion of amoxicillin by methotrexate;
  • azithromycin – reduces bactericidal effects of the drug;
  • ambroxol – increases the concentration of the generic antibiotic in the sputum and bronchial secretions;
  • aspirin, indomethacin and phenylbutazone – inhibit the clearance of the antibiotic, prolonging its effect;
  • dirithromycin, sulfamethoxazole, minocycline, tetracycline, oxytetracycline, clarithromycin, methacycline, doxycycline and erythromycin – interfere with the bactericidal effect;
  • lansoprazoleattention! – increases the risk of side effects relating to the gastrointestinal tract (glossitis, stomatitis, glossotrichia);
  • metronidazole – increases the antibacterial activity of the generic antibiotic;
  • naproxen – may increase the risk of renal dysfunction;
  • rocuronium is pharmacologically incompatible with this remedy;
  • famotidine – accelerates the absorption of the antibiotic;
  • chloramphenicol – inhibits the bactericidal effect of the antibiotic;
  • ethanol – reduces the rate of amoxicillin absorption in the intestine;

Amoxicillin should be taken with caution with oral hormonal contraceptives. The antibiotic may cause a transient decrease of estrogen and progesterone levels in blood and reduce the effects of contraceptives. In this connection, Canadian Pharmacy Mall recommends using other non-hormonal methods of contraception during treatment with this drug.