Pulmonary hypertension (PH) is a group of diseases characterized by a progressive increase in pulmonary vascular resistance that leads to right ventricular failure and premature death. Pulmonary hypertension flows severe with a pronounced decrease of physical endurance and leads to heart failure.
There are various methods to overcome pulmonary hypertension but Canadian HealthCare Mall is going to describe you one by means of Sildenafil Citrate – the generic name of Viagra.
For pulmonary hypertension treatment, Sildenafil should be taken in a dose of 25 mg (1 pill) three times a day. Thus it is necessary to maintain the interval between pills in 6 – 8 hours. The maximum single dose is 50 mg of sildenafil. However, increasing dose from 25 mg to 50 mg should be only when indicated and there is good tolerability. Older people are taking sildenafil in ordinary dosage.
People with impaired renal function, also take Sildenafil at normal doses. However, if the drug is poorly tolerated, it is possible to reduce the dosage to 25 mg twice a day. In liver disease, presence usual Sildenafil dosage is used, but in case of intolerance development, it is necessary to reduce the dosing frequency for two times a day to 25 mg.
In applying high doses (up to 800 mg or more) overdose may be observed. The higher the dose is – the more likely negative symptoms may develop, and the stronger they are expressed. Overdose is manifested:
- hot flashes;
- face redness;
- a headache;
- nasal congestion;
- visual impairment;
- pressure drop;
- digestive disorders.
You may use various drugs that can eliminate symptoms evolved for treating an overdose.
Interaction with Other Drugs
Concomitant use of Sildenafil with drugs affecting isoenzyme CYP3A4 (for example, tetracycline, ketoconazole, erythromycin, cimetidine, saquinavir, ritonavir, etc.) leads to lengthening of action period.
If an antacid is taken singly and simultaneously with sildenafil (e.g. Gastal, Almagel), then there is no interaction between them.
Also, following drugs do not affect sildenafil efficacy:
- diuretics (diuretics);
- antihypertensive drugs;
Sildenafil enhances the effect of sodium nitroprusside, nitroglycerin, and other nitric oxide donors, therefore, it is not recommended for these drugs simultaneous use.
Sildenafil with blockers may cause a severe drop in blood pressure, which manifests itself in dizziness form.
Concomitant use of aspirin does not increase hemorrhagic tendency. Sildenafil side effects have a fairly wide range of side effects that occur with varying frequency.Pharmacists and doctors classify side effects of sildenafil in the incidence of different symptoms:
- Very often – more than one person out of ten;
- Often – symptoms develop in more than in one hundred people, but less than one in ten;
- Uncommon – develop more than one thousand people, but less than one in a hundred;
- Rarely – develop more than one in ten thousand but less than one in a thousand. The intensity of side effects is usually mild or moderate.
Symptoms manifest usually by their own. Moreover, a person’s age does not affect side effects frequency and severity. But dosage of a direct impact on the development of side effects: the greater the amount of drug taken, the more likely unwanted side effects develop.
When using Sildenafil 25 mg three times a day for treatment of pulmonary hypertension, side effects develop in about 1% of people. The use of sildenafil in the low dose three times a day can provoke the following side effects:
- flushing (redness of the skin);
- a headache;
- a migraine;
- burning sensation;
- increased skin sensitivity;
- bleeding in the retina;
- blurred vision;
- color violation;
- eye inflammations;
- eye redness;
- visual acuity deterioration;
- hearing impairment or deafness;
- nasal bleeding;
- a cough;
- stuffy nose;
- digestive disorders;
- gastritis or gastroenteritis;
- gastroesophageal reflux disease;
- abdominal distension;
- dry mouth;
- inflammation of subcutaneous tissue;
- muscle pain or back pain;
- priapism (painful continuous erection);
Watch the video presentation on topic – Sildenafil for pulmonary hypertension treatment:
Analogs of sildenafil are drugs that contain other active components, but have a similar effect. Today the pharmaceutical market is full of the following analogues of sildenafil:
Really speaking there are various medications directed to help people to overcome pulmonary hypertension. Our store provides our customers with medications of high quality and low prices. We do not overestimate combination “price and quality”. We do our best to satisfy our customers’ needs.