Viagra Professional interactions are often neglected. As a result, they experience many side effects and deterioration of health. To avoid these consequences, read the instructions for use. Improper administration may provoke nausea, abdominal pain, headache, redness of the skin. That is why we should not overestimate our strength and take several ED tablets.
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Viagra Professional Interactions: Clinical Researchers
- Sildenafil metabolism is mainly influenced by isoforms ZA4 (major route) and 2C9 (less significant path) of cytochrome P450. That means, inhibitors of these isoenzymes may reduce Sildenafil clearance;
- Cimetidine (800 mg), a nonspecific inhibitor of CYP3A4, in combination with Viagra Professional provoked an increase in Sildenafil plasma concentrations by 56%. Population analysis of clinical studies has demonstrated a decrease in Sildenafil clearance when combined with inhibitors CYP3A4 (such as ketoconazole, erythromycin, cimetidine). However, the incidence of adverse events did not increase for these patients;
- The interaction with a single dose of antacid (hydroxide/magnesium aluminum hydroxide) has not changed Viagra effect. According to the population pharmacokinetic analysis, inhibitors of CYP2C9 (such as tolbutamide, warfarin), CYP2D6 (selective serotonin reuptake inhibitors), thiazides and thiazide diuretics, loop and potassium-sparing diuretics, ACE inhibitors, calcium channel blockers, beta-blockers and inducers of CYP450 metabolism (such as rifampicin, barbiturates) had no effect on the pharmacokinetics of Sildenafil.
Interaction with Other Drugs
Do not take Viagra with similar drugs such as Avanafil (Stendra), Tadalafil (Cialis) or Vardenafil (Levitra). Inform your doctor about all medications you use for erectile dysfunction treatment.
Tell your doctor about all medications you are taking, and those that you plan to take or stopped taking before taking these pills, especially:
- cimetidine;
- bosentan;
- Imatinib;
- nefazodone;
- St. John’s wort;
- antibiotics – clarithromycin, erythromycin, telithromycin;
- antifungals – fluconazole, itraconazole, ketoconazole, miconazole, posaconazole, voriconazole;
- preparations for the treatment of heart failure or blood pressure – amlodipine, amiodarone, nicardipine, quinidine;
- preparations for the treatment of hepatitis C – boceprevir, telaprevir;
- preparations for the treatment of HIV / AIDS – atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;
- medications to treat seizures – carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone, or
drugs for the treatment of tuberculosis – isoniazid, rifabutin, rifampin, rifapentine.
This list is not complete. Other drugs may interact with Sildenafil, including prescription drugs and non-prescription drugs. This guide does not list all possible interactions.
Viagra Professional and Alcohol Interaction
Spirit is a substance that slows down the central nervous system, as well as has a negative impact on the quality of the male sexual properties. Thus, it makes no sense to use medication to improve erection, then drinks alcohol and to reduce its level. There are situations when it is difficult to refuse to drink, but alcohol should be taken in moderation. In such a case we will preserve our health, escape the congestion of heart, and, in addition, receive full pleasure from sexual life.
In general, combining this drug and alcohol a waste of money.
Viagra Professional and Food Interaction
The best option is to take the PDE5 inhibitor before eating – in this case it will act quickly. If you take online pharmacy Viagra after a meal, especially if you eat fatty foods, your body will need more time to digest the drug, and its action will start later.
Viagra Professional and Caffeine Interaction
Many people know that the caffeine contained in coffee and tea should not be mixed with the various stimulants as caffeine itself is a pretty strong aphrodisiac. In addition, coffee cannot be combined with oral contraceptives and sedatives, because such a combination may lead to overexcitation and insomnia.
Viagra Professional interaction with Narcotics
There were no special researches in the relation to this combination. But surely there is a risk to deteriorate your health and a high probability to have troubles with the law. Sildenafil is very well accepted in the larger cities, especially in the places with the active nightlife.
This is not the promotion of a healthy and proper lifestyle. If you take a therapeutic drug, think not only about the consequences, but also about your loved ones. Viagra Professional was created not for experiments on your health, but to improve the quality of life!
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