Alesse is birth control estrogen-progestin combination drug. If ingestion inhibits secretion of gonadotropic hormones. The contraceptive effect is carried out due to several mechanisms.
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As progestin component it contains derivative of 19-nortestosterone – levonorgestrel, surpassing activity of luteosterone (and synthetic analog of latter – Praegninum), it performs on receptor level without prior metabolic transformations. Estrogen component is ethinylestradiol.
Under levonorgestrel influence blockade appears in case of releasing factor (LH and FSH) of the hypothalamus, pituitary gland secretion inhibits gonad-stimulating hormone, which leads to inhibition of maturation and release to fertilize an egg (ovulation). The contraceptive effect is enhanced by ethinylestradiol. It retains high viscosity of cervical mucus (makes it difficult for sperm to penetrate into the uterus).
Along with contraceptive effect when taken regularly normalizes menstrual cycle and helps prevent the development of a number of gynecological diseases, including diseases of tumoral nature.
Indications for Use
In what cases levonorgestrel + ethinylestradiol helps:
- for single-phase products – hormone-dependent functional menstrual disorders (including dysmenorrhoea, menorrhagia without organic cause, premenstrual syndrome).
Attention: Do not appoint a drug using this information section. The effect given by drugs is very different, and birth control pills must be appointed by a doctor.
How Does it Work?
Levonorgestrel and ethinylestradiol are one of the most popular and known hormones. Such medications are released in the form of tablets, capsules for subcutaneous administration, dragees or intrauterine devices.
The action of levonorgestrel is progestagenic and antiestrogenic, due to which the process of ovulation is inhibited preventing pregnancy. These hormones make cervical mucus more viscous, which makes it difficult for the sperm to enter the uterus.
In addition, they affect the growth of the endometrium. So that even if the fertilization of the egg occurs, it will not be able to gain the uterus because of the small thickness of the inner mucosa. The regular intake slows the production of luteinizing and follicle-stimulating hormones, lowers the function of the yellow body.