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Sildenafil citrate is an ingredient in many ED drugs. Regardless of a brand, it has the same principle of action. The active ingredient is an inhibitor of a particular substance – phosphodiesterase (PDE5 inhibitor). Viagra Professional is one of the most popular and successful medicines containing PDE5 Sildenafil.

Discovery of Sildenafil sildenafil

Sildenafil citrate was discovered by British scientists by an accident. In 1992 a group of researchers tested the drug on blood vessels and the ability to treat diseases of the cardiovascular system, specifically, hypertension. As a side effect, many men experienced increased blood flow to the penis – there was observed a significant strengthening of the erection. This was the reason to start a new research but in regard to Sildenafil citrate tablets ability to treat impotence. That is how Viagra appeared.
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Mechanism of Action

The normal process of sexual arousal is always accompanied by the synthesis of numerous cyclic guanosine monophosphate, which has a relaxing effect on the muscles of the penis. It increases blood flow to the penis and strengthens erection what is necessary for certain forms of impotence.

Guanosine monophosphate PDE destroys and blocks the blood flow. Sildenafil citrate substance, destroying phosphodiesterase functions, on the contrary, providing a therapeutic effect.

Instructions for use of any generic drug and the original Viagra contain identical directions. Viagra Professional with Sildenafil active ingredient is prescribed to men in the following cases:

  • erectile dysfunction in the background of the preserved libido;
  • lack of erection;
  • weak erection;
  • the inability to complete a sexual intercourse because of erectile problems.

Sildenafil citrate does not cure impotence, and this should be taken into account at the prescription. The drug solves the problem without a physiological effect on the etiology (cause) of impotence.

That is why it is better to combine the treatment: prescribe Sildenafil tablets and etiological treatment. In addition, the manufacturer indicates the necessary sexual stimulation to achieve the full effect.

Prescription

There are no standards for Sildenafil prescription. The dosing regimen can vary depending on the presence of comorbidities and the individual characteristics of the organism.

You can’t adjust your dose on your own. The only correct Sildenafil substance dosage will be selected by a doctor. The approximate scheme is presented below.

Dosage for Different Diseases

  • The usual recommended dose – 50 mg;
  • In the presence of liver diseases – 25 mg;
  • Renal insufficiency with creatinine clearance less than 30ml / min. – 25 mg;
  • The combined use of certain medications (Itraconazole, Erythromycin, etc.) – 25 mg;
  • Combined with alcohol consumption (moderate amount) – 50 mg.

In some situations, the dosage may be increased to Sildenafil citrate 100 mg.

Age does not affect the dosage. Prescription depends on the general state of health.

The standard way to take Sildenafil citrate tablets – 1 hour before a sexual intercourse.

When is Sildenafil Strictly Prohibited?

Instructions for use of any medicinal product which contains an inhibitor of PDE, Sildenafil in our case, indicates that their use is not always possible.

The main contraindications to PDE inhibitor are:

  • nitrates medications intake;
  • patient’s age under 18 years;
  • lactose intolerance or a disruption mechanism in its absorption, if it’s included in the drug as an inactive ingredient;
  • hypersensitivity to the substance.

Also, manufacturers indicate that in some cases HealthCare and Mall Sildenafil citrate online should be applied under medical supervision. This will be a group of conventional contraindications:

  • The aggravation of gastric ulcer and 12 duodenal ulcers;
  • leukemia, multiple myeloma, thrombocythemia and other diseases that increase the risk of priapism (painful erections continued for about 6 hours);
  • genetically determined retinitis pigmentosa;
  • the recent sharp pathology of the cardiovascular system. Patients in this group are very vulnerable, so excessive sexual activity can become a real threat to their life and health;
  • severe hypotension. Use of Sildenafil for hypotensive men increases the risk of complications;
  • congenital or acquired anatomical features of the penis structure (such as Peyronie’s disease) can become a serious obstacle to the normal action of natural Sildenafil citrate;
  • usually, Sildenafil is not prescribed to women. There will be no proper effect, instead, a woman can experience side effects.

Overdose

The numerous researchers clearly indicate that the severity of overdose symptoms is directly related to the dose of the drug. Reviews of researchers confirm this point.

Repeated Sildenafil dosage exceeding may lead to permissible frequent clinical manifestations:

  1. Rapid heartbeat, a sharp drop in blood pressure, dizziness – in general, the adverse Sildenafil effect on the cardiovascular system;
  2. Cramps;
  3. Dyspepsia (disruption of normal digestion).

The description of clinical Sildenafil researchers included information that a one-time use of PDE inhibitor at a dose of 800 mg or more leads to the symptoms of overdose. Often the treatment of patients was symptomatic. Such procedure as hemodialysis (specialized blood cleansing) proved to be ineffective because of the peculiarities of Sildenafil metabolism.

Sildenafil and Alcohol: Are They Compatible?

It’s not a secret that a man gets a desire to have sex after the alcohol consumption, what is confirmed by the numerous researchers. That is why the manufacturer of active ingredient Sildenafil was obliged to conduct a study on whether alcohol is compatible with PDE.

It’s necessary to pay attention to the impact of alcohol on the body:

  1. The intensive effect on the nervous system: at first, alcohol stimulates it and then depresses.
  2. Low doses of alcohol increase libido, and excess doses – on the contrary.
  3. Alcohol is metabolized in the liver, so intense consumption impacts the organ not the best way.

It’s necessary to pay attention to all the details before starting a treatment with Sildenafil citrate medications (Viagra Professional). The best way is to consult a doctor.