Regular phosphodiesterase-5 inhibitor treatment might be useful for reversing erectile dysfunction. The study was performed using rats to find out if the problem of erectile persists after the end of the treatment.
The Befit of PDE-5 Treatment on Patients with Type-2 Diabetes
Chronic treatment with PDE-5 or phosphodiesterase-5 inhibitor vardenafil for men with type-2 diabetes is safe. In fact, it improved both endothelial function and measures of hemodynamic function along with the reduction in inflammatory markers.
The study found out that there was an improvement in the level of testosterone serum among a subset of hypogonadal diabetic men. This meant that the drug can be used for a new purpose. With more studies, this rate might relate to a reduction in mortality, and would have an even wider effect.
The professionals investigated the effect of endothelial function of chronic treatment with vardenafil on patients with type2 diabetes for about 6 months, and the effects of it for further 6months after the treatment was withdrawn.
Endothelial dysfunction is the trademark of cardiovascular complication in men with type2 diabetes. Thus, the study targeted the endothelial dysfunction regardless of the glycemic control in patients who had type2 Diabetes. There was a strange damage in diabetes compared with other types of vascular disorders.
Interleukin-6 Is Reduced by 60% in 6 Months-Treatment
The motivation for this experiment had come from the earlier meta-analysis that had looked at another phosphodiesterase-5 inhibitor, sildenafil in men who had type 2 diabetes. It had been found that there had been a compelling improvement in their endothelial health. Total 54 men between 40 to 65 years of age participated in the study. All of them had a BMI of 35kg/m2 and had either mild or severe erectile dysfunction. Among the,m about 26 men were randomized to the vardenafil group and 28 of them were randomized to the placebo group.
As expected, the drug had no adverse effect and improved:
- erectile dysfunction;
- endothelial health measures;
- flow meditated dilation.
There was also a decrease in:
- intima-media thickness;
- fibrogen;
- white blood cell cpount;
- red cell distribution width.
Moreover, Canadian Health&Care Mall also states that the treatment showed a decrease in inflammatory marker interleukin. This is one of the most important findings of the treatment. After the withdrawal of the treatment, there was a decrease in flow-meditated dilation.
Rise in the Testosterone Level
The test highlighted a rise in the testosterone level in men having hypogonadal at the baseline. Researchers have said this is because there is an improvement in the microcirculation in the testes. Vardenafil improved the testosterone level to a significant extent. The results on the testosterone were found out on a retrospective analysis. For more information, you can read “Diabetic Men Can Use Testosterone to Improve Sexual Function“.
Other Medication to Treat Type2 Diabetes
There are various medications to treat type2 diabetes but the decision of the medications depends on several factors. Here are some of the examples of some of the possible treatment of diabetes.
Metaformin
This is the first medication prescribed for type2 diabetes. It improves the sensitivity of the body tissues to insulin more effectively. It also reduces the glucose production in the liver.
Sulfonylureas
The medication males your body release more insulin. The examples of these medications are:
- glipizide (Glucotrol)
- glimepiride (Amaryl)
- glyburide (DiaBeta, Glynase)
Megilitinides
It stimulates the pancreas to secrete more insulin but they act much and the effect lasts for a short duration.
Thiazolidinediones
This drug is like metamorphin. It makes the body tissue more sensitive than insulin. However, it has quite serious side effects like increased risk of fracture and heart fail.
DPP-4 Inhibitors
This oral drug helps in reducing blood sugar levels. However, it has a quite a modest effect and do not lead to weight gain. The examples of this oral drug are:
- linagliptin (Tradjenta)
- sitagliptin (Januvia)
- saxagliptin (Onglyza)
Insulin Therapy
There are some people who have type2 diabetes and require insulin therapy. Earlier insulin was used as the last resort but at present, they are prescribed in the early stages because of the benefits.
Normal digestion interferes with insulin and that is the reason it needs to be injected. The doctors prescribe it according to your needs. There are several types of insulin and the options include:
- Insulin lispro (Humalog)
- Insulin glargine (Lantus)
- Insulin glulisine (Apidra)
- Insulin glargine (Lantus)
- Insulin isophane (Humulin N, Novolin N)
- Insulin detemir (Levemir)
However, make sure that you talk to the doctor before taking insulin.
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